ArticleProceedings of the National Academy of Sciences of the United States of America1990
1 alpha,25-dihydroxyvitamin D3 regulates the expression of carbonic anhydrase II in nonerythroid avian bone marrow cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 53 citations in OpenAlex.
- Strontium Functionalization of Biomaterials for Bone Tissue Engineering Purposes: A Biological Point of View.Materials (Basel, Switzerland) · 2022Review
- Effect of dietary 25-hydroxycholecalciferol supplementation and high stocking density on performance, egg quality, and tibia quality in laying hens.Poultry science · 2020Article
- A new experimental system for the extended application of cyclic hydrostatic pressure to cell culture.Journal of biomechanical engineering · 2007Article
- Genomic mechanisms involved in the pleiotropic actions of 1,25-dihydroxyvitamin D3.The Biochemical journal · 1996Review
- Development of a new method for obtaining osteoclasts from endosteal surfaces.In vitro cellular & developmental biology. Animal · 1996Article
- Alternative splicing generates a second isoform of the catalytic A subunit of the vacuolar H(+)-ATPase.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- 17 beta-estradiol suppresses gene expression of tartrate-resistant acid phosphatase and carbonic anhydrase II in ovariectomized rats.Calcified tissue international · 1995Article
- Carbonic anhydrase II gene transcript in cultured osteoclasts from neonatal rats: effect of calcitonin.Cell and tissue research · 1994Article
- Generation of osteoclast-inductive and osteoclastogenic cell lines from the H-2KbtsA58 transgenic mouse.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Osteoclasts express high levels of pp60c-src in association with intracellular membranes.The Journal of cell biology · 1992Article
- Sensitivity to vanadate and isoforms of subunits A and B distinguish the osteoclast proton pump from other vacuolar H+ ATPases.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- 1 alpha,25-dihydroxyvitamin D3 regulates the transcription of carbonic anhydrase II mRNA in avian myelomonocytes.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
1 alpha,25-Dihydroxyvitamin D3 [1,25(OH)2D3], the active metabolite of the steroid hormone vitamin D, is a potent regulator of macrophage and osteoclast differentiation. The mature osteoclast, unlike the circulating monocyte or the tissue macrophage, expresses high levels of carbonic anhydrase II (CAII). This enzyme generates protons and bicarbonate from water and carbon dioxide and is involved in bone resorption and acid-base regulation. To test whether 1,25(OH)2D3 could induce the differentiation of myelomonocytic precursors toward osteoclasts rather than macrophages, we analyzed its effects on the expression of CAII in bone marrow cultures containing precursors common to both cell types. The expression of CAII was markedly increased by 1,25(OH)2D3 in a dose- and time-dependent manner. In bone marrow, this increase occurred at the mRNA and protein levels and was detectable as early as 24 hr after stimulation. 1,25(OH)2D3 was also found to induce CAII expression in a transformed myelomonocytic avian cell line. These results suggest that 1,25(OH)2D3 regulates the level at which myelomonocytic precursors express CAII, an enzyme that is involved in the function of the mature osteoclast.
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