ArticleProceedings of the National Academy of Sciences of the United States of America1990
Role of early genes in pathogenesis of adenovirus pneumonia.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 82 citations in OpenAlex.
- Safety and feasibility of injection with an E1B-55 kDa gene-deleted, replication-selective adenovirus (ONYX-015) into primary carcinomas of the pancreas: a phase I trial.Gene therapy · 2001Trial
- Development of a protocol for whole-lungJournal of biomedical optics · 2024Article
- Donor IL-17 receptor A regulates LPS-potentiated acute and chronic murine lung allograft rejection.JCI insight · 2023Article
- Human Adenovirus Type 4 Comprises Two Major Phylogroups with Distinct Replicative Fitness and Virulence Phenotypes.Journal of virology · 2022Article
- Article
- Human lung ex vivo infection models.Cell and tissue research · 2017Review
- Gene delivery to the airway.Current protocols in human genetics · 2013Review
- High temporal resolution imaging reveals endosomal membrane penetration and escape of adenoviruses in real time.Methods in molecular biology (Clifton, N.J.) · 2013Article
- Article
- Functions of type II pneumocyte-derived vascular endothelial growth factor in alveolar structure, acute inflammation, and vascular permeability.The American journal of pathology · 2010Article
- Immunocompetent syngeneic cotton rat tumor models for the assessment of replication-competent oncolytic adenovirus.Virology · 2007Article
- Replication properties of human adenovirus in vivo and in cultures of primary cells from different animal species.Journal of virology · 2006Article
- The early responses of VEGF and its receptors during acute lung injury: implication of VEGF in alveolar epithelial cell survival.Critical care (London, England) · 2006Article
- Identification of subgenus C adenoviruses by fiber-based multiplex PCR.Journal of clinical microbiology · 2004Article
- Inhibition of chemokine expression by adenovirus early region three (E3) genes.Journal of virology · 2002Article
- Role of the type 5 adenovirus gene encoding the early region 1B 55-kDa protein in pulmonary pathogenesis.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Expression of gp19K increases the persistence of transgene expression from an adenovirus vector in the mouse lung and liver.Journal of virology · 1997Article
- Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo.Journal of virology · 1996Article
- The role of human adenovirus early region 3 proteins (gp19K, 10.4K, 14.5K, and 14.7K) in a murine pneumonia model.Journal of virology · 1996Article
- Gene therapy for cystic fibrosis: challenges and future directions.The Journal of clinical investigation · 1995Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Intranasal inoculation of type 5 adenovirus into the cotton rat Sigmodon hispidus produces a pneumonia pathologically similar to that in humans, and it, therefore, provides an excellent animal model to investigate the pathogenesis of this disease. The goal of this study was to test the hypothesis that accumulation of viral structural proteins is responsible for a major portion of the cell-damage-producing disease. Since viral DNA replication is essential for synthesis of the viral structural proteins, which are products of late genes, the hypothesis was tested using mutants defective in genes required for DNA synthesis. Most experiments were done with the conditionally lethal temperature-sensitive (ts) mutant H5ts125, which contains a mutation in the early region 2A (E2A) gene encoding the DNA-binding protein. The data show that infection with 1 x 10(9.0) plaque-forming units of H5ts125 induced a pneumonia that was as extensive and qualitatively the same as that after wild-type adenovirus type 5 infection, although H5ts125 did not replicate to produce infectious virus. When cotton rats were infected with 1 x 10(8.0) plaque-forming units of wild-type adenovirus type 5 or H5ts125, the pneumonias that followed were pathologically similar; in the latter phases, however, wild-type virus produced slightly more extensive pneumonia than did H5ts125, probably because its replication permitted infection of more susceptible cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.