Evidence map›Paper›PMID 21669333›Full record

ArticleNeurobiology of aging2011

Epigenetic mechanisms in Alzheimer's disease: progress but much to do.

Robert Balazs, Jeffrey Vernon, John Hardy

Abstract readComment
PubMed Publisher
In one paragraph

Article in Neurobiology of aging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Hypermethylation ofOxidative medicine and cellular longevity · 2018
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Epigenetic studies in Alzheimer's disease: current findings, caveats, and considerations for future studies.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2013
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Robert BalazsReta Lilla Weston Research Laboratories and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK. rbalazs@tiscali.co.uk
Jeffrey Vernon
John Hardy

Funding

Medical Research Council G0701075
6 · The paper itself

Abstract

The interesting review from Mastroeni and colleagues highlights recent progress on epigenetic analysis of Alzheimer's disease, but it also illustrates how much we still need to do.

Indexed as

AgingAlzheimer DiseaseEpigenesis, GeneticGenetic Predisposition to DiseaseHumans

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.