ArticleJournal of theoretical biology2011
Coupling biochemistry and hydrodynamics captures hyperactivated sperm motility in a simple flagellar model.
Article in Journal of theoretical biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Embodied behavioural complexity in a ciliated microorganism.Nature communications · 2026Article
- A Framework for Generating Radial and Surface-Oriented Regularized Stokeslets.Fluids (Basel, Switzerland) · 2022Article
- Collective dynamics of sperm cells.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Methodological considerations for examining the relationship between sperm morphology and motility.Molecular reproduction and development · 2020Review
- Flagellar ultrastructure suppresses buckling instabilities and enables mammalian sperm navigation in high-viscosity media.Journal of the Royal Society, Interface · 2019Article
- Effects of cell morphology and attachment to a surface on the hydrodynamic performance of unicellular choanoflagellates.Journal of the Royal Society, Interface · 2019Article
- Intracellular Ca2+ threshold reversibly switches flagellar beat off and on.Biology of reproduction · 2018Article
- The actin cytoskeleton of the mouse sperm flagellum is organized in a helical structure.Journal of cell science · 2018Article
- From flagellar undulations to collective motion: predicting the dynamics of sperm suspensions.Journal of the Royal Society, Interface · 2018Article
- Image-based model of the spectrin cytoskeleton for red blood cell simulation.PLoS computational biology · 2017Article
- Progesterone Accelerates the Completion of Sperm Capacitation and Activates CatSper Channel in Spermatozoa from the Rhesus Macaque.Biology of reproduction · 2015Article
- Network analyses of sperm-egg recognition and binding: ready to rethink fertility mechanisms?Omics : a journal of integrative biology · 2014Article
- Mathematical modeling of calcium signaling during sperm hyperactivation.Molecular human reproduction · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Hyperactivation in mammalian sperm is characterized by highly asymmetrical waveforms and an increase in the amplitude of flagellar bends. It is important for the sperm to be able to achieve hyperactivated motility in order to reach and fertilize the egg. Calcium (Ca(2+)) dynamics are known to play a large role in the initiation and maintenance of hyperactivated motility. Here we present an integrative model that couples the CatSper channel mediated Ca(2+) dynamics of hyperactivation to a mechanical model of an idealized sperm flagellum in a 3-d viscous, incompressible fluid. The mechanical forces are due to passive stiffness properties and active bending moments that are a function of the local Ca(2+) concentration along the length of the flagellum. By including an asymmetry in bending moments to reflect an asymmetry in the axoneme's response to Ca(2+), we capture the transition from activated motility to hyperactivated motility. We examine the effects of elastic properties of the flagellum and the Ca(2+) dynamics on the overall swimming patterns. The swimming velocities of the model flagellum compare well with data for hyperactivated mouse sperm.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.