ArticleBMC microbiology2011
New V. cholerae atypical El Tor variant emerged during the 2006 epidemic outbreak in Angola.
Article in BMC microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 41 citations in OpenAlex.
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- Resistance ofFrontiers in pharmacology · 2023Review
- Phylogenetic and antimicrobial drug resistance analysis ofMicrobial genomics · 2021Article
- Recent Vibrio cholerae O1 Epidemic Strains Are Unable To Replicate CTXΦ Prophage Genome.mSphere · 2021Article
- Antimicrobial resistance ofAfrican journal of laboratory medicine · 2018Review
- Comparative genome analysis of VSP-II and SNPs reveals heterogenic variation in contemporary strains of Vibrio cholerae O1 isolated from cholera patients in Kolkata, India.PLoS neglected tropical diseases · 2017Article
- Identification of AtypicalFrontiers in microbiology · 2017Article
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- The seventh pandemic Vibrio cholerae O1 El Tor isolate in China has undergone genetic shifts.Journal of clinical microbiology · 2014Article
- A new integrative conjugative element detected in Haitian isolates of Vibrio cholerae non-O1/non-O139.Research in microbiology · 2013Article
- Vibrio cholerae O1 epidemic variants in Angola: a retrospective study between 1992 and 2006.Frontiers in microbiology · 2013Article
- Cholera outbreaks in Nigeria are associated with multidrug resistant atypical El Tor and non-O1/non-O139 Vibrio cholerae.PLoS neglected tropical diseases · 2013Article
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- Comparative genome analysis of non-toxigenic non-O1 versus toxigenic O1Genomics discoveryArticle
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5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundV. cholerae is the etiological agent of cholera, a major public health concern in most developing countries. Virulence of V. cholerae relies on the powerful cholera toxin, encoded by the CTX prophage. The emergence of new pathogenic variants in the recent years has been mostly associated with new CTX prophage rearrangements.
resultsIn this retrospective study, we show that the epidemic V. cholerae O1 El Tor strain responsible for the 2006 outbreak in Angola is clonally and genetically different from El Tor strains circulating in the 1990s in the same area. Strains from 2006 carry ICEVchAng3 of the SXT/R391 family. This ICE is associated with a narrower multidrug resistance profile compared to the one conferred by plasmid p3iANG to strains of the 1990s. The CTX prophage carried by 2006 El Tor strains is characterized by rstR(ET) and ctxB(Cla) alleles organized in a RS1-RS2-Core array on chromosome I. Interestingly, the newly emerging atypical strain belongs to a clade previously known to comprise only clinical isolates from the Indian subcontinent that also contain the same ICE of the SXT/R391 family.
conclusionsOur findings remark the appearance of a novel V. cholerae epidemic variant in Africa with a new CTXΦ arrangement previously described only in the Indian Subcontinent.
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