ArticleAnnals of human genetics2011
Selecting SNPs to identify ancestry.
Article in Annals of human genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The paradoxical extinction: Exploring signatures of assortative mating as a possible mechanism that maintains canonical Red Wolf genetic ancestry in the American Gulf Coast canids.The Journal of heredity · 2026Article
- Combining whole genome sequencing and non-adaptive group testing for large-scale ethnicity screens.BMC bioinformatics · 2025Article
- Genetic Ancestry and Lung Cancer in Latin American Patients: A Crucial Step for Understanding a Diverse Population.Clinical lung cancer · 2025Review
- Engaging for equity: Lessons from a cross-sector partnership addressing prostate cancer risk in the black community.Research involvement and engagement · 2025Article
- PCCA variant rs16957301 is a novel AKI risk genotype-specific for patients who receive ICI treatment: Real-world evidence from all of us cohort.European journal of cancer (Oxford, England : 1990) · 2024Article
- Opioid use disorder risk alleles in self-reported assigned African American/Afro-Caribbean and European biogeographical genetic ancestry groups and in males and females.The pharmacogenomics journal · 2024Article
- Genomic medicine for the 21Annals of the Royal College of Surgeons of England · 2024Article
- Metabolic diversity in human populations and correlation with genetic and ancestral geographic distances.Molecular genetics and metabolism · 2022Article
- Inferred Ancestral Origin of Cancer Cell Lines Associates with Differential Drug Response.International journal of molecular sciences · 2021Article
- The Advantages and Challenges of Diversity in Pharmacogenomics: Can Minority Populations Bring Us Closer to Implementation?Clinical pharmacology and therapeutics · 2019Review
- Imprint of assortative mating on the human genome.Nature human behaviour · 2018Article
- A small number of candidate gene SNPs reveal continental ancestry in African Americans.Annals of human genetics · 2013Article
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Authors and funding
4 authors.
Funding
Abstract
An individual's genotypes at a group of single-nucleotide polymorphisms (SNPs) can be used to predict that individual's ethnicity or ancestry. In medical studies, knowledge of a subject's ancestry can minimize possible confounding, and in forensic applications, such knowledge can help direct investigations. Our goal is to select a small subset of SNPs, from the millions already identified in the human genome, that can predict ancestry with a minimal error rate. The general form for this variable selection procedure is to estimate the expected error rates for sets of SNPs using a training dataset and consider those sets with the lowest error rates given their size. The quality of the estimate for the error rate determines the quality of the resulting SNPs. As the apparent error rate performs poorly when either the number of SNPs or the number of populations is large; we propose a new estimate, the Improved Bayesian Estimate. We demonstrate that selection procedures based on this estimate produce small sets of SNPs that can accurately predict ancestry. We also provide a list of the 100 optimal SNPs for identifying ancestry.
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