Evidence map›Paper›PMID 21668908›Full record

ArticleAnnals of human genetics2011

Successful aging shows linkage to chromosomes 6, 7, and 14 in the Amish.

Digna R Velez Edwards, John R Gilbert, Lan Jiang, Paul J Gallins, Laura Caywood, Marilyn Creason, Denise Fuzzell, Clare Knebusch, Charles E Jackson, Margaret A Pericak-Vance and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of human genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.1field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. WDR12 and HIVEP3 are contributors to cognitive preservation in Amish SuperAgers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Article
  4. Alzheimer's disease plasma biomarkers in the Midwestern Amish.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  5. Article
  6. Article
  7. The GGLEAM Study: Understanding Glaucoma in the Ohio Amish.International journal of environmental research and public health · 2021
    Article
  8. Genetic and epigenetic regulation of human aging and longevity.Biochimica et biophysica acta. Molecular basis of disease · 2019
    Review
  9. Genetic cartography of longevity in humans and mice: Current landscape and horizons.Biochimica et biophysica acta. Molecular basis of disease · 2018
    Review
  10. Genome-Wide Association Study and Linkage Analysis of the Healthy Aging Index.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015
    Article
  11. Article
  12. Article
  13. Review
  14. Association of healthy aging with parental longevity.Age (Dordrecht, Netherlands) · 2013
    Article
  15. Article
  16. Article
  17. Article
  18. The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Digna R Velez EdwardsDr. John T. Macdonald Foundation Department of Human Genetics and John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.
John R Gilbert
Lan Jiang
Paul J Gallins
Laura Caywood
Marilyn Creason
Denise Fuzzell
Clare Knebusch
Charles E Jackson
Margaret A Pericak-Vance
Jonathan L Haines
William K Scott
University of Miami · USVanderbilt University · USBaylor Scott & White Medical Center - Temple · USCenter for Human Genetics · USDr. John T. Macdonald Foundation · US

Funding

Genetic Studies of Dementia in the AmishR01AG019085 · NIA · VANDERBILT UNIVERSITY · PI HAINES, JONATHAN L · 2001 to 2011
$11.0M
Genetic Studies of Successful Aging in the AmishR01AG019726 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SCOTT, WILLIAM K. · 2003 to 2007
$2.9M
NIA NIH HHS AG019085NIA NIH HHS AG019726NIA NIH HHS R01 AG019085NIA NIH HHS R01 AG019726
6 · The paper itself

Abstract

Successful aging (SA) is a multidimensional phenotype involving preservation of cognitive ability, physical function, and social engagement throughout life. Multiple components of SA are heritable, supporting a genetic component. The Amish are genetically and socially isolated with homogeneous lifestyles, making them a suitable population for studying the genetics of SA. DNA and measures of SA were collected on 214 cognitively intact Amish individuals over age 80. Individuals were grouped into a 13-generation pedigree using the Anabaptist Genealogy Database. A linkage screen of 5944 single nucleotide polymorphisms (SNPs) was performed using 12 informative subpedigrees with an affected-only 2-point and multipoint linkage analysis. Eleven SNPs produced 2-point LOD scores >2, suggestive of linkage. Multipoint linkage analyses, allowing for heterogeneity, detected significant LOD scores on chromosomes 6 (HLOD = 4.50), 7 (LOD*= 3.11), and 14 (HLOD = 4.17), suggesting multiple new loci underlying SA.

Indexed as

Chromosomes, Human, Pair 14Chromosomes, Human, Pair 6Chromosomes, Human, Pair 7Genetic LinkageAgedAged, 80 and overFemaleGenome-Wide Association StudyHumansLod ScoreLongevityMalePedigreePennsylvaniaPhenotypePolymorphism, Single Nucleotide

Identifiers

PMID21668908
PMCPMC3756593
OpenAlexW1488336305

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.