ArticleInfluenza and other respiratory viruses2011
Sexual dimorphism in lung function responses to acute influenza A infection.
Article in Influenza and other respiratory viruses, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
- Responsiveness to Ipratropium Bromide in Male and Female Patients with Mild to Moderate Chronic Obstructive Pulmonary Disease.EBioMedicine · 2017Trial
- Biological sex influences immune response to influenza infection in juvenile outbred mice.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- Sex differences in immune responses to viruses, bacteria and vaccines.Nature immunology · 2026Review
- The effects of e-cigarette use on asthma severity in adult BALB/c mice.Experimental physiology · 2026Article
- The X Factor in Immunity: Sex Differences Shaped by the X Chromosome.Immunological reviews · 2026Review
- Biological sex differences after high and low doses of influenza A virus infection during obesity.Frontiers in immunology · 2026Article
- Biological Sex Differences after High and Low Doses of Influenza A Virus Infection in a Diet-induced Obesity Mouse Model.bioRxiv : the preprint server for biology · 2025Article
- Role of Atypical MAPK p38 Signaling in the Progression of Influenza A-Induced Acute Lung Injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Partial amelioration of a chronic cigarette-smoke-induced phenotype in mice by switching to electronic cigarettes.Archives of toxicology · 2025Article
- Estrogen and viral infection.Frontiers in immunology · 2025Review
- Sex-based differences in persistent lung inflammation following influenza infection of juvenile outbred mice.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- Sex Differences during Influenza A Virus Infection and Vaccination and Comparison of Cytokine and Antibody Responses between Plasma and Serum Samples.Pathogens (Basel, Switzerland) · 2024Article
- An infant mouse model of influenza-driven nontypeableInfection and immunity · 2024Article
- H7N7 viral infection elicits pronounced, sex-specific neuroinflammatory responsesFrontiers in cellular neuroscience · 2024Article
- Mechanisms and consequences of sex differences in immune responses.Nature reviews. Nephrology · 2024Review
- Obesity amplifies influenza virus-driven disease severity in male and female mice.Mucosal immunology · 2023Article
- New insights on the potential effect of progesterone in Covid-19: Anti-inflammatory and immunosuppressive effects.Immunity, inflammation and disease · 2023Review
- Respiratory Health Effects of In Vivo Sub-Chronic Diesel and Biodiesel Exhaust Exposure.International journal of molecular sciences · 2023Article
- Sex and molecular differences in cardiovascular parameters at peak influenza disease in mice.Physiological genomics · 2023Article
- Biological Sex and Pregnancy Affect Influenza Pathogenesis and Vaccination.Current topics in microbiology and immunology · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMales are generally more susceptible to respiratory infections; however, there are few data on the physiological responses to such infections in males and females.
objectivesTo determine whether sexual dimorphism exists in the physiological/inflammatory responses of weanling and adult BALB/c mice to influenza.
methodsWeanling and adult mice of both sexes were inoculated with influenza A or appropriate control solution. Respiratory mechanics, responsiveness to methacholine (MCh), viral titre and bronchoalveolar lavage (BAL) cellular inflammation/cytokines were measured 4 (acute) and 21 (resolution) days post-inoculation.
resultsAcute infection impaired lung function and induced hyperresponsiveness and cellular inflammation in both sexes at both ages. Males and females responded differently with female mice developing greater abnormalities in tissue damping and elastance and greater MCh responsiveness at both ages. BAL inflammation, cytokines and lung viral titres were similar between the sexes. At resolution, all parameters had returned to baseline levels in adults and weanling males; however, female weanlings had persisting hyperresponsiveness.
conclusionsWe identified significant differences in the physiological responses of male and female mice to infection with influenza A, which occurred in the absence of variation in viral titre and cellular inflammation.
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