ArticleInfluenza and other respiratory viruses2011
Obese mice have increased morbidity and mortality compared to non-obese mice during infection with the 2009 pandemic H1N1 influenza virus.
Article in Influenza and other respiratory viruses, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47 citing papers in PubMed, 74 citations in OpenAlex.
- Article
- Sex Differences in the Impact of Obesity on Immunity.Immunological reviews · 2026Review
- Body Size and Risk of Death During the 1918 Influenza Pandemic in Alaska.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Review
- Thoracic adipose tissue contributes to severe virus infection of the lung.International journal of obesity (2005) · 2023Article
- Obesity dysregulates the pulmonary antiviral immune response.Nature communications · 2023Article
- Orthopedic Manifestations and Post-COVID-19 Infection.Journal of pharmacy & bioallied sciences · 2023Article
- Obesity Is Associated with Attenuated Tissue Immunity in COVID-19.American journal of respiratory and critical care medicine · 2023Article
- Obesity exacerbates influenza-induced respiratory disease via the arachidonic acid-p38 MAPK pathway.Frontiers in pharmacology · 2023Article
- Correlation between Type I Interferon Associated Factors and COVID-19 Severity.International journal of molecular sciences · 2022Review
- Frequency of orthopedic manifestations in COVID-19 patients.Journal of Taibah University Medical Sciences · 2022Article
- Diet-induced obesity in mice impairs host defense againstAmerican journal of physiology. Lung cellular and molecular physiology · 2022Article
- Obesity, a major risk factor for immunity and severe outcomes of COVID-19.Bioscience reports · 2021Review
- The Mechanism behind Influenza Virus Cytokine Storm.Viruses · 2021Review
- Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge.EBioMedicine · 2021Review
- Obesity, COVID-19 and innate immunometabolism.The British journal of nutrition · 2021Article
- The Inflammatory Profile of Obesity and the Role on Pulmonary Bacterial and Viral Infections.International journal of molecular sciences · 2021Review
- Review
- COVID-19 Severity in Obesity: Leptin and Inflammatory Cytokine Interplay in the Link Between High Morbidity and Mortality.Frontiers in immunology · 2021Review
- Dysregulated Inflammation During Obesity: Driving Disease Severity in Influenza Virus and SARS-CoV-2 Infections.Frontiers in immunology · 2021Review
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8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundObesity has been identified as an independent risk factor for severe or fatal infection with 2009 pandemic H1N1 influenza (2009 pH1N1), but was not previously recognized for previous pandemic or seasonal influenza infections.
objectivesOur aim was to evaluate the role of obesity as an independent risk factor for severity of infection with 2009 pH1N1, seasonal H1N1, or a pathogenic H1N1 influenza virus.
methodsDiet-induced obese (DIO) and their non-obese, age-matched control counterparts were inoculated with a 2009 pH1N1, A/California/04/2009 (CA/09), current seasonal H1N1, A/NY/312/2001 (NY312), or highly pathogenic 1918-like H1N1, A/Iowa/Swine/1931 (Sw31), virus.
resultsFollowing inoculation with CA/09, DIO mice had higher mortality (80%) than control mice (0%) and lost more weight during infection. No effect of obesity on morbidity and mortality was observed during NY312 or Sw31 infection. Influenza antigen distribution in the alveolar regions of the lungs was more pronounced in DIO than control mice during CA/09 infection at 3 days post-inoculation (dpi), despite similar virus titers. During CA/09 infection, localized interferon-β and proinflammatory cytokine protein responses in the lungs were significantly lower in DIO than control mice. Conversely, serum cytokine concentrations were elevated in DIO, but not control mice following infection with CA/09. The effect of obesity on differential immune responses was abrogated during NY312 or Sw31 infection.
conclusionsTogether, these data support epidemiologic reports that obesity may be a risk factor for severe 2009 pandemic H1N1 influenza infection, but the role of obesity in seasonal or highly virulent pandemic influenza infection remains unclear.
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