ArticleJournal of abnormal psychology2011
Consideration of the BDNF gene in relation to two phenotypes: hoarding and obesity.
Article in Journal of abnormal psychology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Meta-analysis of genome-wide association studies of hoarding symptoms in 27,537 individuals.Translational psychiatry · 2022Pooled it
- Genetics of OCD and Related Disorders; Searching for Shared Factors.Current topics in behavioral neurosciences · 2021Pooled it
- The relationships between hoarding-related behaviours and disordered eating in a non-clinical adult sample: an exploratory study.BMC psychology · 2026Article
- The BDNF Val66Met polymorphism serves as a potential marker of body weight in patients with psychiatric disorders.AIMS neuroscience · 2024Review
- Genomics of Obsessive-Compulsive Disorder and Related Disorders: What the Clinician Needs to Know.The Psychiatric clinics of North America · 2023Review
- WNT/β-catenin pathway and circadian rhythms in obsessive-compulsive disorder.Neural regeneration research · 2022Review
- Possible actions of cannabidiol in obsessive-compulsive disorder by targeting the WNT/β-catenin pathway.Molecular psychiatry · 2022Review
- Hoarding Disorder: Development in Conceptualization, Intervention, and Evaluation.Focus (American Psychiatric Publishing) · 2021Article
- Influence of childhood trauma and brain-derived neurotrophic factor Val66Met polymorphism on posttraumatic stress symptoms and cortical thickness.Scientific reports · 2019Article
- An association study between DLGAP1 rs11081062 and EFNA5 rs26728 polymorphisms with obsessive-compulsive disorder in a Chinese Han population.Neuropsychiatric disease and treatment · 2015Article
- An initial investigation of the relationships between hoarding and smoking.Psychiatry research · 2014Article
- Medical conditions in geriatric hoarding disorder patients.Aging & mental health · 2014Article
- Novel "thrifty" models of increased eating behaviour.Current psychiatry reports · 2013Review
- Anxiety and affective disorder comorbidity related to serotonin and other neurotransmitter systems: obsessive-compulsive disorder as an example of overlapping clinical and genetic heterogeneity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Neurogenetics and Epigenetics in Impulsive Behaviour: Impact on Reward Circuitry.Journal of genetic syndromes & gene therapy · 2012Article
- Diet, genetics, and disease: a focus on the middle East and north Africa region.Journal of nutrition and metabolism · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The gene coding for the brain derived neurotrophic factor (BDNF) has emerged as an interesting candidate for multiple brain and brain disorder-related phenomena. The primary aim of the present investigation was to consider the relationship between the BDNF Val66Met variant and two phenotypes: compulsive hoarding as a symptom dimension of obsessive-compulsive disorder (OCD), and body mass index (BMI). We examined the BDNF gene in a large (N=301) clinical sample of probands with OCD. Participants were classified as hoarding or nonhoarding using a strict, multimeasure grouping approach. Results revealed that the Val/Val genotype was linked with hoarding classification and more severe hoarding behaviors, as well as greater BMI levels. Hoarding status was also associated with greater BMI scores, with individuals in the hoarding group being far more likely to be classified as obese compared with the nonhoarding group. Our findings may provide a distinct avenue through which hoarding and BMI could be linked. These findings are suggestive of a complex gene, body weight, and psychopathology relationship wherein a primitive, survival "thrifty gene" strategy may be conserved and represented in a subgroup of humans manifesting severe hoarding symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.