ArticleMycopathologia2011
A rat model of neonatal candidiasis demonstrates the importance of lipases as virulence factors for Candida albicans and Candida parapsilosis.
Article in Mycopathologia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Update on the Pathogenesis, Virulence, and Treatment ofPathogens & immunity · 2022Review
- Vulvovaginal Candidiasis: A Current Understanding and Burning Questions.Journal of fungi (Basel, Switzerland) · 2020Review
- Attack, Defend and Persist: How the Fungal Pathogen Candida auris was Able to Emerge Globally in Healthcare Environments.Mycopathologia · 2019Review
- Candida parapsilosis: from Genes to the Bedside.Clinical microbiology reviews · 2019Review
- Investigation ofFrontiers in microbiology · 2017Article
- Article
- Neonatal Candidiasis: New Insights into an Old Problem at a Unique Host-Pathogen Interface.Current fungal infection reports · 2015Article
- The Genomic Aftermath of Hybridization in the Opportunistic Pathogen Candida metapsilosis.PLoS genetics · 2015Article
- Different Candida parapsilosis clinical isolates and lipase deficient strain trigger an altered cellular immune response.Frontiers in microbiology · 2015Article
- The spectrum of fungi that infects humans.Cold Spring Harbor perspectives in medicine · 2014Review
- The Candida pathogenic species complex.Cold Spring Harbor perspectives in medicine · 2014Review
- Secreted Candida parapsilosis lipase modulates the immune response of primary human macrophages.Virulence · 2014Article
- Human endothelial cells internalize Candida parapsilosis via N-WASP-mediated endocytosis.Infection and immunity · 2013Article
- Galectin-3 plays an important role in protection against disseminated candidiasis.Medical mycology · 2013Article
- Candida parapsilosis and the neonate: epidemiology, virulence and host defense in a unique patient setting.Expert review of anti-infective therapy · 2012Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The host factors that contribute to the increased susceptibility of preterm neonates to invasive candidiasis have not been fully identified. In addition, there has been a lack of suitable models to study this problem. We show that rat pups, similar to premature neonates, display increased susceptibility to experimental Candida albicans infection. Further, we find that both C. albicans and Candida parapsilosis lipase disruptant mutants exhibit decreased virulence in rat pups, demonstrating the utility of the model to evaluate the impact of specific genes in disease pathogenesis. Our findings highlight the contribution of lipases to the virulence of C. albicans and C. parapsilosis and provide a new system to study the increased susceptibility of neonates to Candida infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.