SynthesisBrain structure & function2012
Neuroanatomic changes and their association with cognitive decline in mild cognitive impairment: a meta-analysis.
Synthesis in Brain structure & function, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Gray Matter Atrophy in Amnestic Mild Cognitive Impairment: A Voxel-Based Meta-Analysis.Frontiers in aging neuroscience · 2021Pooled it
- Chronic cigarette smoking is linked with structural alterations in brain regions showing acute nicotinic drug-induced functional modulations.Behavioral and brain functions : BBF · 2016Pooled it
- Specific and disease stage-dependent episodic memory-related brain activation patterns in Alzheimer's disease: a coordinate-based meta-analysis.Brain structure & function · 2015Pooled it
- Effects of computerized cognitive training on structure‒function coupling and topology of multiple brain networks in people with mild cognitive impairment: a randomized controlled trial.Alzheimer's research & therapy · 2023Trial
- Combined treatment with escitalopram and memantine increases gray matter volume and cortical thickness compared to escitalopram and placebo in a pilot study of geriatric depression.Journal of affective disorders · 2020Trial
- Assessing Microstructural and Molecular Brain Changes in Early Cognitive Decline Using Multiparametric 3T Magnetic Resonance Imaging.Neurology international · 2026Article
- The Impact of Chronic Pain on Cognitive Function.Brain sciences · 2025Review
- Altered interactions between attentional networks in older adults with mild cognitive impairment.Heliyon · 2025Article
- Chronic pain and cognitive dysfunction: clinical manifestations, underlying mechanisms, and emerging therapeutic strategies.Frontiers in neuroscience · 2025Review
- Correlates and Brain Substrates of Happiness in Community-Dwelling Older Adults in India.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- Alterations in Gray Matter Structural Networks in Amnestic Mild Cognitive Impairment: A Source-Based Morphometry Study.Journal of Alzheimer's disease : JAD · 2024Article
- Longitudinal changes in gray matter correspond to changes in cognition across the lifespan: implications for theories of cognition.Neurobiology of aging · 2023Article
- Temporal lobe atrophy as a potential predictor of functional outcome in older adults with acute ischemic stroke.Acta neurologica Belgica · 2023Article
- Article
- Association between cerebrospinal fluid clusterin and biomarkers of Alzheimer's disease pathology in mild cognitive impairment: a longitudinal cohort study.Frontiers in aging neuroscience · 2023Article
- The Influence of Processing Speed, Attention, and Inhibition on Texas Functional Living Scale Performance.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2022Article
- Poor sleep accelerates hippocampal and posterior cingulate volume loss in cognitively normal healthy older adults.Journal of sleep research · 2022Article
- Intra- and interhemispheric symmetry of subcortical brain structures: a volumetric analysis in the aging human brain.Brain structure & function · 2022Article
- Concurrent Structural and Functional Patterns in Patients With Amnestic Mild Cognitive Impairment.Frontiers in aging neuroscience · 2022Article
- Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Mild cognitive impairment (MCI) is an acquired syndrome characterised by cognitive decline not affecting activities of daily living. Using a quantitative meta-analytic approach, we aimed to identify consistent neuroanatomic correlates of MCI and how they are related to cognitive dysfunction. The meta-analysis enrols 22 studies, involving 917 MCI (848 amnestic MCI) patients and 809 healthy controls. Only studies investigating local changes in grey matter and reporting whole-brain results in stereotactic coordinates were included and analysed using the activation likelihood estimation approach. Probabilistic cytoarchitectonic maps were used to compare the localization of the obtained significant effects to histological areas. A correlation between the probability of grey matter changes and cognitive performance of MCI patients was performed. In MCI patients, the meta-analysis revealed three significant clusters of convergent grey matter atrophy, which were mainly situated in the bilateral amygdala and hippocampus, extending to the left medial temporal pole and thalamus, as well as in the bilateral precuneus. A sub-analysis in only amnestic MCI revealed a similar pattern. A voxel-wise analysis revealed a correlation between grey matter reduction and cognitive decline in the right hippocampus and amygdala as well as in the left thalamus. This study provides convergent evidence of a distinct neuroanatomical pattern in MCI. The correlation analysis with cognitive-mnestic decline further highlights the impact of limbic structures and the linkage with data from a functional neuroimaging database provides additional insight into underlying functions. Although different pathologies are underlying MCI, the observed neuroanatomical pattern of structural changes may reflect the common clinical denominator of cognitive impairment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.