ArticleHuman genetics2011
X-inactivation and X-reactivation: epigenetic hallmarks of mammalian reproduction and pluripotent stem cells.
Article in Human genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Multiscale chromatin modeling of chromosome X structural changes upon inactivation highlights the differential regulatory mechanism ofbioRxiv : the preprint server for biology · 2026Article
- Hbo1 and Msl complexes preserve differential compaction and H3K27me3 marking of active and inactive X chromosomes during mitosis.Nature cell biology · 2025Article
- Translating weighted probabilistic bits to synthetic genetic circuits.The plant genome · 2025Article
- An emerging link between lncRNAs and cancer sex dimorphism.Human genetics · 2024Review
- Active DNA damage response signaling initiates and maintains meiotic sex chromosome inactivation.Nature communications · 2022Article
- Modulation of DNA/RNA Methylation by Small-Molecule Modulators and Their Implications in Cancer.Sub-cellular biochemistry · 2022Article
- Interrogating Epigenome toward Personalized Approach in Cutaneous Melanoma.Journal of personalized medicine · 2021Review
- Induced 2C Expression and Implantation-Competent Blastocyst-like Cysts from Primed Pluripotent Stem Cells.Stem cell reports · 2019Article
- Signatures of replication timing, recombination, and sex in the spectrum of rare variants on the human X chromosome and autosomes.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Human Germ Cell Tumors are Developmental Cancers: Impact of Epigenetics on Pathobiology and Clinic.International journal of molecular sciences · 2019Review
- Epigenetic differences between naïve and primed pluripotent stem cells.Cellular and molecular life sciences : CMLS · 2018Review
- A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Pluripotent stem cells and livestock genetic engineering.Transgenic research · 2016Review
- Xist imprinting is promoted by the hemizygous (unpaired) state in the male germ line.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Genome wide DNA methylation profiles provide clues to the origin and pathogenesis of germ cell tumors.PloS one · 2015Article
- NaNog: A pluripotency homeobox (master) molecule.Global cardiology science & practice · 2015Article
- Derivation of mesenchymal stromal cells from canine induced pluripotent stem cells by inhibition of the TGFβ/activin signaling pathway.Stem cells and development · 2014Article
- The sex bias in systemic sclerosis: on the possible mechanisms underlying the female disease preponderance.Clinical reviews in allergy & immunology · 2014Review
- Human active X-specific DNA methylation events showing stability across time and tissues.European journal of human genetics : EJHG · 2014Article
- Generation and characterization of leukemia inhibitory factor-dependent equine induced pluripotent stem cells from adult dermal fibroblasts.Stem cells and development · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
X-chromosome inactivation is an epigenetic hallmark of mammalian development. Chromosome-wide regulation of the X-chromosome is essential in embryonic and germ cell development. In the male germline, the X-chromosome goes through meiotic sex chromosome inactivation, and the chromosome-wide silencing is maintained from meiosis into spermatids before the transmission to female embryos. In early female mouse embryos, X-inactivation is imprinted to occur on the paternal X-chromosome, representing the epigenetic programs acquired in both parental germlines. Recent advances revealed that the inactive X-chromosome in both females and males can be dissected into two elements: repeat elements versus unique coding genes. The inactive paternal X in female preimplantation embryos is reactivated in the inner cell mass of blastocysts in order to subsequently allow the random form of X-inactivation in the female embryo, by which both Xs have an equal chance of being inactivated. X-chromosome reactivation is regulated by pluripotency factors and also occurs in early female germ cells and in pluripotent stem cells, where X-reactivation is a stringent marker of naive ground state pluripotency. Here we summarize recent progress in the study of X-inactivation and X-reactivation during mammalian reproduction and development as well as in pluripotent stem cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.