ArticleJournal of computational neuroscience2012
Dependence of spontaneous neuronal firing and depolarisation block on astroglial membrane transport mechanisms.
Article in Journal of computational neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 79 citations in OpenAlex.
- Nonlinear dynamics of seizure suppression via optogenetic modulation of neuron-astrocyte interaction.Scientific reports · 2026Article
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- The Na+/K+-ATPase generically enables deterministic bursting in class I neurons by shearing the spike-onset bifurcation structure.PLoS computational biology · 2024Article
- Uncertainty quantification and sensitivity analysis of neuron models with ion concentration dynamics.PloS one · 2024Article
- Parameter Inference for an Astrocyte Model using Machine Learning Approaches.bioRxiv : the preprint server for biology · 2023Article
- An Algorithm Based on a Cable-Nernst Planck Model Predicting Synaptic Activity throughout the Dendritic Arbor with Micron Specificity.Neuroinformatics · 2023Article
- Slow ion concentration oscillations and multiple states in neuron-glia interaction-insights gained from reduced mathematical models.Frontiers in network physiology · 2023Article
- Interneuronal dynamics facilitate the initiation of spike block in cortical microcircuits.Journal of computational neuroscience · 2022Article
- A unified physiological framework of transitions between seizures, sustained ictal activity and depolarization block at the single neuron level.Journal of computational neuroscience · 2022Article
- An electrodiffusive neuron-extracellular-glia model for exploring the genesis of slow potentials in the brain.PLoS computational biology · 2021Article
- Activity-mediated accumulation of potassium induces a switch in firing pattern and neuronal excitability type.PLoS computational biology · 2021Article
- Dynamics of a neuron-glia system: the occurrence of seizures and the influence of electroconvulsive stimuli : A mathematical and numerical study.Journal of computational neuroscience · 2020Article
- An electrodiffusive, ion conserving Pinsky-Rinzel model with homeostatic mechanisms.PLoS computational biology · 2020Article
- Finite Element Simulation of Ionic Electrodiffusion in Cellular Geometries.Frontiers in neuroinformatics · 2020Article
- Mitochondrial dysfunction and role in spreading depolarization and seizure.Journal of computational neuroscience · 2019Article
- A Kirchhoff-Nernst-Planck framework for modeling large scale extracellular electrodiffusion surrounding morphologically detailed neurons.PLoS computational biology · 2018Article
- Astrocytic Kir4.1 channels and gap junctions account for spontaneous epileptic seizure.PLoS computational biology · 2018Article
- The influence of depolarization block on seizure-like activity in networks of excitatory and inhibitory neurons.Journal of computational neuroscience · 2017Article
- Effect of Ionic Diffusion on Extracellular Potentials in Neural Tissue.PLoS computational biology · 2016Article
- The influence of potassium concentration on epileptic seizures in a coupled neuronal model in the hippocampus.Cognitive neurodynamics · 2016Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposed to a sufficiently high extracellular potassium concentration ([K( + )]₀), the neuron can fire spontaneous discharges or even become inactivated due to membrane depolarisation ('depolarisation block'). Since these phenomena likely are related to the maintenance and propagation of seizure discharges, it is of considerable importance to understand the conditions under which excess [K( + )]₀ causes them. To address the putative effect of glial buffering on neuronal activity under elevated [K( + )](o) conditions, we combined a recently developed dynamical model of glial membrane ion and water transport with a Hodgkin-Huxley type neuron model. In this interconnected glia-neuron model we investigated the effects of natural heterogeneity or pathological changes in glial membrane transporter density by considering a large set of models with different, yet empirically plausible, sets of model parameters. We observed both the high [K( + )]₀-induced duration of spontaneous neuronal firing and the prevalence of depolarisation block to increase when reducing the magnitudes of the glial transport mechanisms. Further, in some parameter regions an oscillatory bursting spiking pattern due to the dynamical coupling of neurons and glia was observed. Bifurcation analyses of the neuron model and of a simplified version of the neuron-glia model revealed further insights about the underlying mechanism behind these phenomena. The above insights emphasise the importance of combining neuron models with detailed astroglial models when addressing phenomena suspected to be influenced by the astroglia-neuron interaction. To facilitate the use of our neuron-glia model, a CellML version of it is made publicly available.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.