ArticleMolecular biology reports2012
Polymorphisms of the bovine luteinizing hormone/choriogonadotropin receptor (LHCGR) gene and its association with superovulation traits.
Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 22 citations in OpenAlex.
- A framework for identifying and prioritizing SNPs in genes of the hypothalamic- pituitary-gonadal axis in Guzerat cattle using amplicon-based NGS.BMC genomic data · 2025Article
- Genotyping of cows by LHCGR, FSHR loci, and determination of the level of ovulation depending on the expression of the studied genes.Open veterinary journal · 2023Article
- The relationship between the variants in the 5'-untranslated regions of equine chorionic gonadotropin genes and serum equine chorionic gonadotropin levels.Asian-Australasian journal of animal sciences · 2017Article
- Adrenal cortex expression quantitative trait loci in a German Holstein × Charolais cross.BMC genetics · 2016Article
- Effect of luteinizing hormone/choriogonadotropin receptor (LHCGR) gene on chicken reproductive traits.Molecular biology reports · 2013Article
- Effects of PGR and ESRα genotypes on the pregnancy rates after embryo transfer in Luxi cattle.Molecular biology reports · 2013Article
- Association of a missense mutation in the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) with superovulation traits in Chinese Holstein heifers.Journal of animal science and biotechnology · 2012Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The major limitation to the development of embryo transfer technique in cattle is the highly variable between individuals in ovulatory response to FSH-induced superovulation. The objective of this study was to identify a predictor to forecast superovulation response on the basis of associations between superovulation performance and gene polymorphism, variation in the bovine luteinizing hormone/choriogonadotropin receptor (LHCGR) gene was investigated using PCR-single-strand conformational (PCR-SSCP) and DNA sequencing. Four single nucleotide polymorphisms (SNPs) of G51656T, A51703G, A51726G and G51737A were identified at the intron 9 of the LHCGR gene in 171 Chinese Holstein cows treated for superovulation, and evaluated its associations with superovulatory response. Association analysis showed that these four SNPs had significant effects on the total number of ova (TNO) (P < 0.05). Moreover, the A51703G and A51726G polymorphisms significantly associated with the number of transferable embryos (NTE) (P < 0.05). In addition, significant additive effect on TNO was detected in polymorphisms of G51656T (P < 0.05) and A51703G (P < 0.01), and the A51703G polymorphism also had significant additive effects on NTE (P < 0.01). These results indicate that LHCGR gene is a potential marker for superovulation response and can be used to predict the most appropriate dose of FSH for superovulation in Chinese Holstein cows.
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