ArticleMetabolomics : Official journal of the Metabolomic Society2011
Stable isotope resolved metabolomics of lung cancer in a SCID mouse model.
Article in Metabolomics : Official journal of the Metabolomic Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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Who cites it
79 citing papers in PubMed.
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- Nanoparticle-based itaconate treatment recapitulates low-cholesterol/low-fat diet-induced atherosclerotic plaque resolution.Cell reports · 2024Article
- Stable isotope-resolved metabolomics analyses of metabolic phenotypes reveal variable glutamine metabolism in different patient-derived models of non-small cell lung cancer from a single patient.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Challenges of Spatially Resolved Metabolism in Cancer Research.Metabolites · 2024Review
- Cyclin D1 extensively reprograms metabolism to support biosynthetic pathways in hepatocytes.The Journal of biological chemistry · 2023Article
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- Bayesian kinetic modeling for tracer-based metabolomic data.BMC bioinformatics · 2023Article
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- NMR Analysis of Carboxylate Isotopomers ofAnalytical chemistry · 2021Article
- Exosome-mediated delivery of RNA and DNA for gene therapy.Cancer letters · 2021Article
- NMR Methods for Determining Lipid Turnover via Stable Isotope Resolved Metabolomics.Metabolites · 2021Article
- An Ion Chromatography-Ultrahigh-Resolution-MSAnalytical chemistry · 2021Article
- NMR-Based Metabolomics.Advances in experimental medicine and biology · 2021Article
- Chronic cold exposure enhances glucose oxidation in brown adipose tissue.EMBO reports · 2020Article
19 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
We have determined the time course of [U-(13)C]-glucose utilization and transformations in SCID mice via bolus injection of the tracer in the tail vein. Incorporation of (13)C into metabolites extracted from mouse blood plasma and several tissues (lung, heart, brain, liver, kidney, and skeletal muscle) were profiled by NMR and GC-MS, which helped ascertain optimal sampling times for different target tissues. We found that the time for overall optimal (13)C incorporation into tissue was 15-20 min but with substantial differences in (13)C labeling patterns of various organs that reflected their specific metabolism. Using this stable isotope resolved metabolomics (SIRM) approach, we have compared the (13)C metabolite profile of the lungs in the same mouse with or without an orthotopic lung tumor xenograft established from human PC14PE6 lung adenocarcinoma cells. The (13)C metabolite profile shows considerable differences in [U-(13)C]-glucose transformations between the two lung tissues, demonstrating the feasibility of applying SIRM to investigate metabolic networks of human cancer xenograft in the mouse model.
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