ArticleNature neuroscience2011
Synaptically driven state transitions in distal dendrites of striatal spiny neurons.
Article in Nature neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
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Who cites it
89 citing papers in PubMed.
- Auditory associative learning drives synaptic responses in tail of the striatum spiny projection neurons.iScience · 2026Article
- Striatal endocannabinoids drive one-shot learning.Nature neuroscience · 2026Article
- A basolateral amygdala to dorsolateral striatum projection modulates stimulus-evoked motor behavior.Neuron · 2026Article
- Cholinergic interneuron control of GABAergic circuits targeting spiny projection neurons is disrupted in parkinsonian models.bioRxiv : the preprint server for biology · 2026Article
- Accumbal calcium-permeable AMPA receptors orchestrate neuronal ensembles underlying social attachment.Nature communications · 2026Article
- State-dependent modulation of spiny projection neurons controls levodopa-induced dyskinesia in a mouse model of Parkinson's disease.Science advances · 2025Article
- Article
- Mouse and human striatal projection neurons compared - somatodendritic arbor, spines and in silico analyses.PLoS computational biology · 2025Article
- From avoidance to new action: the multifaceted role of the striatal indirect pathway.Nature reviews. Neuroscience · 2025Review
- Safety learning induces postsynaptic potentiation of direct pathway spiny projection neurons in the tail of the striatum.bioRxiv : the preprint server for biology · 2025Article
- State-dependent modulation of spiny projection neurons controls levodopa-induced dyskinesia in a mouse model of Parkinson's disease.bioRxiv : the preprint server for biology · 2025Article
- CaCell reports · 2024Article
- GABAergic regulation of striatal spiny projection neurons depends upon their activity state.PLoS biology · 2024Article
- Cell-Type Specific Connectivity of Whisker-Related Sensory and Motor Cortical Input to Dorsal Striatum.eNeuro · 2024Article
- Article
- Updating the striatal-pallidal wiring diagram.Nature neuroscience · 2024Review
- Making time and space for calcium control of neuron activity.Current opinion in neurobiology · 2023Review
- Distributed dopaminergic signaling in the basal ganglia and its relationship to motor disability in Parkinson's disease.Current opinion in neurobiology · 2023Review
- Spiny projection neurons exhibit transcriptional signatures within subregions of the dorsal striatum.Cell reports · 2023Article
- Pathway-specific alterations in striatal excitability and cholinergic modulation in a SAPAP3 mouse model of compulsive motor behavior.Cell reports · 2023Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Striatal spiny neurons (SPNs) associate a diverse array of cortically processed information to regulate action selection. But how this is done by SPNs is poorly understood. A key step in this process is the transition of SPNs from a hyperpolarized 'down state' to a sustained, depolarized 'up state'. These transitions are thought to reflect a sustained synaptic barrage, involving the coordination of hundreds of pyramidal neurons. Indeed, in mice, simulation of cortical input by glutamate uncaging on proximal dendritic spines produced potential changes in SPNs that tracked input time course. However, brief glutamate uncaging at spines on distal dendrites evoked somatic up states lasting hundreds of milliseconds. These regenerative events depended upon both NMDA receptors and voltage-dependent Ca(2+) channels. Moreover, they were bidirectionally regulated by dopamine receptor signaling. This capacity not only changes our model of how up states are generated in SPNs, it also has fundamental implications for the associative process underlying action selection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.