ArticleThe EMBO journal2011
Modulation of Tcf3 repressor complex composition regulates cdx4 expression in zebrafish.
Article in The EMBO journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Mechanical Tensions Regulate Gene Expression in theInternational journal of molecular sciences · 2024Article
- Transcription factor E4F1 as a regulator of cell life and disease progression.Science advances · 2023Review
- The Fgf/Erf/NCoR1/2 repressive axis controls trophoblast cell fate.Nature communications · 2023Article
- Impaired Blastocyst Formation inInternational journal of molecular sciences · 2023Article
- IQ-Switch is a QF-based innocuous, silencing-free, and inducible gene switch system in zebrafish.Communications biology · 2021Article
- The Molecular and Pathophysiological Functions of Members of the LNX/PDZRN E3 Ubiquitin Ligase Family.Molecules (Basel, Switzerland) · 2020Review
- Wnt-PLC-IPNature communications · 2020Article
- LNX1/LNX2 proteins: functions in neuronal signalling and beyond.Neuronal signaling · 2018Review
- The Wnt Transcriptional Switch: TLE Removal or Inactivation?BioEssays : news and reviews in molecular, cellular and developmental biology · 2018Review
- Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.Molecular neurobiology · 2017Article
- The guanine nucleotide exchange factor Net1 facilitates the specification of dorsal cell fates in zebrafish embryos by promoting maternal β-catenin activation.Cell research · 2017Article
- Article
- Lnx2 ubiquitin ligase is essential for exocrine cell differentiation in the early zebrafish pancreas.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Inhibition of neural crest formation by Kctd15 involves regulation of transcription factor AP-2.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Caudal genes in blood development and leukemia.Annals of the New York Academy of Sciences · 2012Review
- Maintaining embryonic stem cell pluripotency with Wnt signaling.Development (Cambridge, England) · 2011Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The caudal homeobox (cdx) gene family is critical for specification of caudal body formation and erythropoiesis. In zebrafish, cdx4 expression is controlled by the Wnt pathway, but the molecular mechanism of this regulation is not fully understood. Here, we provide evidence that Tcf3 suppresses cdx4 expression through direct binding to multiple sites in the cdx4 gene regulatory region. Tcf3 requires corepressor molecules such as Groucho (Gro)/TLE and HDAC1 for activity. Using zebrafish embryos and cultured mammalian cells, we show that the transcription factor E4f1 derepresses cdx4 by dissociating corepressor proteins from Tcf3 without inhibiting its binding to cis-regulatory sites in the DNA. Further, the E3 ubiquitin ligase Lnx2b, acting as a scaffold protein irrespective of its enzymatic activity, counteracts the effects of E4f1. We propose that the modulation of Tcf3 repressor function by E4f1 assures precise and robust regulation of cdx4 expression in the caudal domain of the embryo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.