ArticleJournal of pediatric gastroenterology and nutrition2011
Nucleotide sequence of the Na+/H+ exchanger-8 in patients with congenital sodium diarrhea.
Article in Journal of pediatric gastroenterology and nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Congenital Diarrhea: A Case Report on Challenges in Both Prenatal and Postnatal Diagnosis.Case reports in obstetrics and gynecology · 2026Article
- Up-regulation of NHE8 by somatostatin ameliorates the diarrhea symptom in infectious colitis mice model.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2018Article
- Pathophysiology of Intestinal NaCellular and molecular gastroenterology and hepatology · 2017Article
- Congenital diarrhoeal disorders: advances in this evolving web of inherited enteropathies.Nature reviews. Gastroenterology & hepatology · 2015Review
- Human intestinal epithelial cell line SK-CO15 is a new model system to study Na(+)/H(+) exchanger 3.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Small intestinal ion transport.Current opinion in gastroenterology · 2012Review
- SLC9/NHE gene family, a plasma membrane and organellar family of Na⁺/H⁺ exchangers.Molecular aspects of medicineReview
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Sodium absorption by the intestine is mediated by brush border Na/H exchangers, which include the NHE3 and NHE8 isoforms. We demonstrated a maturational decrease in NHE8 and increase in NHE3 in mouse intestine mRNA abundance and brush border membrane protein abundance, indicating a developmental switch of isoforms. Congenital sodium diarrhea is a rare autosomal recessive disorder characterized by polyhydramnios, hyponatremia, metabolic acidosis, and diarrhea with a high sodium content. Previous studies using intestinal brush border membrane vesicles from patients with this disorder have demonstrated a decrease in Na/H exchanger activity. Because some patients with congenital sodium diarrhea improve with age and knowing the developmental switch from NHE8 to NHE3, NHE8 may be a candidate gene for this disorder. We sequenced NHE8 from 5 patients with this disorder and found no disease-causing homozygous mutations. Although brush border membrane Na/H exchange activity may be decreased, exonic mutations in NHE8 cannot account for this disorder in these subjects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.