ArticleAging2011
Embryonic anti-aging niche.
Article in Aging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Exploring potential strategies to enhance memory and cognition in aging mice.F1000Research · 2023Article
- Current Thoughts of Notch's Role in Myoblast Regulation and Muscle-Associated Disease.International journal of environmental research and public health · 2021Review
- Why stem/progenitor cells lose their regenerative potential.World journal of stem cells · 2021Review
- Embryonic stem cell-derived extracellular vesicles promote the recovery of kidney injury.Stem cell research & therapy · 2021Article
- Study of Natural Longlife Juvenility and Tissue Regeneration in Caudate Amphibians and Potential Application of Resulting Data in Biomedicine.Journal of developmental biology · 2021Review
- Embryonic stem cell microenvironment enhances proliferation of human retinal pigment epithelium cells by activating the PI3K signaling pathway.Stem cell research & therapy · 2020Article
- Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin.Aging · 2020Article
- Embryonic stem cell-derived extracellular vesicles enhance the therapeutic effect of mesenchymal stem cells.Theranostics · 2019Article
- Article
- Cellular senescence in aging and osteoarthritis.Acta orthopaedica · 2016Review
- Review
- Age-specific functional epigenetic changes in p21 and p16 in injury-activated satellite cells.Stem cells (Dayton, Ohio) · 2015Article
- The Intricate Interplay between Mechanisms Underlying Aging and Cancer.Aging and disease · 2015Review
- Article
- Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration.Nature communications · 2014Article
- Pharmacological inhibition of myostatin/TGF-β receptor/pSmad3 signaling rescues muscle regenerative responses in mouse model of type 1 diabetes.Acta pharmacologica Sinica · 2013Article
- Induction of cell proliferation in old rat liver can reset certain gene expression levels characteristic of old liver to those associated with young liver.Age (Dordrecht, Netherlands) · 2013Article
- Age-associated changes in the ecological niche: implications for mesenchymal stem cell aging.Stem cell research & therapy · 2013Review
- hESC-secreted proteins can be enriched for multiple regenerative therapies by heparin-binding.Aging · 2013Article
- Regenerative capacity of old muscle stem cells declines without significant accumulation of DNA damage.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Although functional organ stem cells persist in the old, tissue damage invariably overwhelms tissue repair, ultimately causing the demise of an organism. The poor performance of stem cells in an aged organ, such as skeletal muscle, is caused by the changes in regulatory pathways such as Notch, MAPK and TGF-β, where old differentiated tissue actually inhibits its own regeneration. This perspective analyzes the current literature on regulation of organ stem cells by their young versus old niches and suggests that determinants of healthy and prolonged life might be under a combinatorial control of cell cycle check point proteins and mitogens, which need to be tightly balanced in order to promote tissue regeneration without tumor formation. While responses of adult stem cells are regulated extrinsically and age-specifically, we put forward experimental evidence suggesting that embryonic cells have an intrinsic youthful barrier to aging and produce soluble pro-regenerative proteins that signal the MAPK pathway for rejuvenating myogenesis. Future identification of this activity will improve our understanding of embryonic versus adult regulation of tissue regeneration suggesting novel strategies for organ rejuvenation. Comprehensively, the current intersection of aging and stem cell science indicates that if the age-imposed decline in the regenerative capacity of stem cells was understood, the debilitating lack of organ maintenance in the old could be ameliorated and perhaps, even reversed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.