ArticleBrain : a journal of neurology2011
Olfactocentric paralimbic cortex morphology in adolescents with bipolar disorder.
Article in Brain : a journal of neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Cortical Thickness in Middle and Older Aged Adults With Bipolar Disorder Across Six International Sites.Bipolar disorders · 2026Article
- Towards a neurodevelopmental model of bipolar disorder: a critical review of trait- and state-related functional neuroimaging in adolescents and young adults.Molecular psychiatry · 2025Review
- Differences in Quantification of the Metabotropic Glutamate Receptor 5 Across Bipolar Disorder and Major Depressive Disorder.Biological psychiatry · 2023Article
- Discovering the neuronal dynamics in major depressive disorder using Hidden Markov Model.Frontiers in human neuroscience · 2023Article
- Rethinking "aggression" and impulsivity in bipolar disorder: Risk, clinical and brain circuitry features.Journal of affective disorders · 2022Article
- Graph theory analysis of whole brain functional connectivity to assess disturbances associated with suicide attempts in bipolar disorder.Translational psychiatry · 2022Article
- Neuroimaging Studies of Brain Structure in Older Adults with Bipolar Disorder: A Review.Journal of psychiatry and brain science · 2022Article
- Identification of bipolar disorder using a combination of multimodality magnetic resonance imaging and machine learning techniques.BMC psychiatry · 2020Article
- Spontaneous low-frequency fluctuations in the neural system for emotional perception in major psychiatric disorders: amplitude similarities and differences across frequency bandsJournal of psychiatry & neuroscience : JPN · 2019Article
- Gray and white matter differences in adolescents and young adults with prior suicide attempts across bipolar and major depressive disorders.Journal of affective disorders · 2019Article
- Longitudinal Diffusion Tensor Imaging Study of Adolescents and Young Adults With Bipolar Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2018Article
- Neurobiological Commonalities and Distinctions Among Three Major Psychiatric Diagnostic Categories: A Structural MRI Study.Schizophrenia bulletin · 2018Article
- Brain structure in women at risk of postpartum psychosis: an MRI study.Translational psychiatry · 2017Article
- Effects of ANK3 variation on gray and white matter in bipolar disorder.Molecular psychiatry · 2017Article
- Abnormal baseline brain activity in Alzheimer's disease patients with depression: a resting-state functional magnetic resonance imaging study.Neuroradiology · 2017Article
- Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder.The American journal of psychiatry · 2017Article
- Brain circuitry associated with the development of substance use in bipolar disorder and preliminary evidence for sexual dimorphism in adolescents.Journal of neuroscience research · 2017Article
- Anterior Cortical Development During Adolescence in Bipolar Disorder.Biological psychiatry · 2016Article
- Brain Structural Effects of Psychopharmacological Treatment in Bipolar Disorder.Current neuropharmacology · 2015Review
- Resting-state brain function in schizophrenia and psychotic bipolar probands and their first-degree relatives.Psychological medicine · 2015Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The olfactocentric paralimbic cortex plays a critical role in the regulation of emotional and neurovegetative functions that are disrupted in core features of bipolar disorder. Adolescence is thought to be a critical period in both the maturation of the olfactocentric paralimbic cortex and in the emergence of bipolar disorder pathology. Together, these factors implicate a central role for the olfactocentric paralimbic cortex in the development of bipolar disorder and suggest that abnormalities in this cortex may be expressed by adolescence in the disorder. We tested the hypothesis that differences in olfactocentric paralimbic cortex structure are a morphological feature in adolescents with bipolar disorder. Subjects included 118 adolescents (41 with bipolar disorder and 77 healthy controls). Cortical grey matter volume differences between adolescents with and without bipolar disorder were assessed with voxel-based morphometry analyses of high-resolution structural magnetic resonance imaging scans. Compared with healthy comparison adolescents, adolescents with bipolar disorder demonstrated significant volume decreases in olfactocentric paralimbic regions, including orbitofrontal, insular and temporopolar cortices. Findings in these regions survived small volume correction (P < 0.05, corrected). Volume decreases in adolescents with bipolar disorder were also noted in inferior prefrontal and superior temporal gyri and cerebellum. The findings suggest that abnormalities in the morphology of the olfactocentric paralimbic cortex may contribute to the bipolar disorder phenotype that emerges in adolescence. The morphological development of the olfactocentric paralimbic cortex has received little study. The importance of these cortices in emotional and social development, and support for a central role for these cortices in the development of bipolar disorder, suggest that study of the development of these cortices in health and in bipolar disorder is critically needed.
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