ArticleJournal of immunology (Baltimore, Md. : 1950)2011
A critical role for dendritic cells in the formation of lymphatic vessels within tertiary lymphoid structures.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 69 citations in OpenAlex.
- Lymphatic Vessel Density or Area Are Not Reliable Prognostic Factors in Oral Cancer.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026Article
- Artemisinin-Related Therapeutic Strategies for Autoimmune Thyroiditis: Chemokine-Receptor Networks, Spatial Thyroid Biology, and Molecular Mechanisms.Drug design, development and therapy · 2026Review
- An Introduction to Tertiary Lymphoid Structures in Cancer.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Tertiary lymphoid organs in wild boar exposed to a low-virulent isolate of African swine fever virus.The veterinary quarterly · 2024Article
- Review
- The Role of Interleukin-7 in the Formation of Tertiary Lymphoid Structures and Their Prognostic Value in Gastrointestinal Cancers.Journal of immunotherapy and precision oncology · 2022Review
- Stromal and Immune Cell Dynamics in Tumor Associated Tertiary Lymphoid Structures and Anti-Tumor Immune Responses.Frontiers in cell and developmental biology · 2022Review
- Tertiary lymphoid structure and B-cell-related pathways: A potential target in tumor immunotherapy.Oncology letters · 2021Review
- Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts.Cell reports · 2021Article
- Insights Into Unveiling a Potential Role of Tertiary Lymphoid Structures in Metastasis.Frontiers in molecular biosciences · 2021Review
- Lymphatic drainage from bronchus-associated lymphoid tissue in tolerant lung allografts promotes peripheral tolerance.The Journal of clinical investigation · 2020Article
- Human Lung Conventional Dendritic Cells Orchestrate Lymphoid Neogenesis during Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2020Article
- Role of iBALT in Respiratory Immunity.Current topics in microbiology and immunology · 2020Review
- Chronic Inflammation: A Common Promoter in Tertiary Lymphoid Organ Neogenesis.Frontiers in immunology · 2019Review
- Tertiary Lymphoid Organs in Cancer Immunology: Mechanisms and the New Strategy for Immunotherapy.Frontiers in immunology · 2019Review
- Lymphatic Vessel Network Structure and Physiology.Comprehensive Physiology · 2018Review
- Characterization of ectopic lymphoid structures in different types of acute renal allograft rejection.Clinical and experimental immunology · 2018Article
- Immune Cell Infiltration and Tertiary Lymphoid Structures as Determinants of Antitumor Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2018Review
- Ectopic germinal center and megalin defect in primary Sjogren syndrome with renal Fanconi syndrome.Arthritis research & therapy · 2017Article
- Regulation of Lymph Node Vascular-Stromal Compartment by Dendritic Cells.Trends in immunology · 2016Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Ectopic, or tertiary, lymphoid aggregates often form in chronically inflamed areas. Lymphatic vessels, as well as high endothelial venules, form within these lymphoid aggregates, but the mechanisms underlying their development are poorly understood. Overexpression of the chemokine CCL21 in the thyroid of transgenic mice leads to formation of lymphoid aggregates containing topologically segregated T and B lymphocytes, dendritic cells (DCs), and specialized vasculature, including Lyve-1(+)/Prox-1(+) lymphatic vessels. In this article, we show that adoptive transfer of mature CD4(+) T cells into animals expressing CCL21 in a RAG-deficient background promotes the influx of host NK cells and DCs into the thyroid and the formation of new lymphatic vessels within 10 d. This process is dependent on the expression of lymphotoxin ligands by host cells, but not by the transferred CD4(+) T cells. Ablation of host DCs, but not NK cells, reduces the formation of new lymphatic vessels in the thyroid. Taken together, these data suggest a critical role for CD11c(+) DCs in the induction of lymphangiogenesis in tertiary lymphoid structures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.