ArticleApplied and environmental microbiology2011
The transcriptional response of Listeria monocytogenes during adaptation to growth on lactate and diacetate includes synergistic changes that increase fermentative acetoin production.
Article in Applied and environmental microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 54 citations in OpenAlex.
- Resilience and evolutionary insights in PPI networks: comparative analysis of node resilience and centrality measures.Frontiers in genetics · 2025Article
- Metabolic reprogramming in the food-borne pathogen Listeria monocytogenes as a critical defence against acid stress.FEMS microbiology letters · 2024Review
- The influence of stress factors on selected phenotypic and genotypic features of Listeria monocytogenes - a pilot study.BMC microbiology · 2023Article
- Unravelling the Molecular Mechanisms Underlying the Protective Effect of Lactate on the High-Pressure Resistance ofBiomolecules · 2021Article
- Comparative Review of the Responses ofGenes · 2020Review
- Global Transcriptional Response of Three Highly Acid-Tolerant Field Strains ofMicroorganisms · 2019Article
- Transcriptome Sequencing ofFrontiers in microbiology · 2019Article
- Article
- Transcriptional Response ofFrontiers in microbiology · 2018Article
- Transcriptomic Analysis of the Adaptation of Listeria monocytogenes to Growth on Vacuum-Packed Cold Smoked Salmon.Applied and environmental microbiology · 2015Article
- VirR-Mediated Resistance of Listeria monocytogenes against Food Antimicrobials and Cross-Protection Induced by Exposure to Organic Acid Salts.Applied and environmental microbiology · 2015Article
- Omics approaches in food safety: fulfilling the promise?Trends in microbiology · 2014Review
- Enzyme-based listericidal nanocomposites.Scientific reports · 2013Article
- Exploration of the role of the non-coding RNA SbrE in L. monocytogenes stress response.International journal of molecular sciences · 2012Article
- Listeria monocytogenes shows temperature-dependent and -independent responses to salt stress, including responses that induce cross-protection against other stresses.Applied and environmental microbiology · 2012Article
- Toward a Systemic Understanding of Listeria monocytogenes Metabolism during Infection.Frontiers in microbiology · 2012Article
- Antibacterial efficacy of nisin, bacteriophage P100 and sodium lactate against Listeria monocytogenes in ready-to-eat sliced pork ham.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The organic acids lactate and diacetate are commonly used in combination in ready-to-eat foods because they show synergistic ability to inhibit the growth of Listeria monocytogenes. Full-genome microarrays were used to investigate the synergistic transcriptomic responses of two L. monocytogenes strains, H7858 (serotype 4b) and F6854 (serotype 1/2a), to these two organic acids under conditions representing osmotic and cold stress encountered in foods. Strains were exposed to brain heart infusion (BHI) broth at 7°C with 4.65% water-phase (w.p.) NaCl at pH 6.1 with (i) 2% w.p. potassium lactate, (ii) 0.14% w.p. sodium diacetate, (iii) the combination of both at the same levels, or (iv) no organic acids as a control. RNA was extracted 8 h after exposure, during lag phase, to capture gene transcription changes during adaptation to the organic acid stress. Significant differential transcription of 1,041 genes in H7858 and 640 genes in F6854 was observed in at least one pair of the 4 different treatments. The effects of combined treatment with lactate and diacetate included (i) synergistic transcription differences for 474 and 209 genes in H7858 and F6854, respectively, (ii) differential transcription of genes encoding cation transporters and ABC transporters of metals, and (iii) altered metabolism, including induction of a nutrient-limiting stress response, reduction of menaquinone biosynthesis, and a shift from fermentative production of acetate and lactate to energetically less favorable, neutral acetoin. These data suggest that additional treatments that interfere with cellular energy generation processes could more efficiently inhibit the growth of L. monocytogenes.
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