ArticleJournal of bacteriology2011
A sulfite respiration pathway from Thermus thermophilus and the key role of newly identified cytochrome c₅₅₀.
Article in Journal of bacteriology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Taxonomic, genomic, and ecological insights into a novel Flavobacteriaceae strain from coastal tidal flats.BMC microbiology · 2025Article
- A CsoR family transcriptional regulator, TTHA1953, controls the sulfur oxidation pathway in Thermus thermophilus HB8.The Journal of biological chemistry · 2023Article
- Expression, Purification, andBio-protocol · 2022Article
- The Heterotrophic Bacterium Cupriavidus pinatubonensis JMP134 Oxidizes Sulfide to Sulfate with Thiosulfate as a Key Intermediate.Applied and environmental microbiology · 2020Article
- Functional mononuclear molybdenum enzymes: challenges and triumphs in molecular cloning, expression, and isolation.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2020Review
- VLDL Induced Modulation of Nitric Oxide Signalling and Cell Redox Homeostasis in HUVEC.Oxidative medicine and cellular longevity · 2017Article
- Sulfite-oxidizing enzymes.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2015Review
- Multilayered polyelectrolyte microcapsules: interaction with the enzyme cytochrome C oxidase.PloS one · 2014Article
- Functional dissection of the multi-domain di-heme cytochrome c(550) from Thermus thermophilus.PloS one · 2013Article
- Microbial pathways in colonic sulfur metabolism and links with health and disease.Frontiers in physiology · 2012Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sulfite, produced for instance during amino acid metabolism, is a very reactive and toxic compound. Various detoxification mechanisms exist, but sulfite oxidoreductases (SORs) are one of the major actors in sulfite remediation in bacteria and animals. Here we describe the existence of an operon in the extreme thermophilic bacterium Thermus thermophilus HB8 encoding both a SOR and a diheme c-type cytochrome. The in vitro analysis clearly showed that the newly identified cytochrome c₅₅₀ acts as an acceptor of the electrons generated by the SOR enzyme during the oxidation of sulfite. The electrons are then rapidly shuttled via cytochrome c₅₅₂ to the terminal ba₃- and caa₃-type oxidases, thereby unveiling a novel electron transfer pathway, linking sulfite oxidation to oxygen reduction in T. thermophilus: sulfite → SOR(HB8) → cytochrome c₅₅₀ → cytochrome c₅₅₂ → ba₃ oxidase/caa₃ oxidase → O₂. The description of the complete pathway reveals that electrons generated during sulfite oxidation by the SOR are funneled into the respiratory chain, participating in the energy production of T. thermophilus.
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