ReviewJournal of autoimmunity2011
To B or not to B: role of B cells in pathogenesis of arthritis in HLA transgenic mice.
Review in Journal of autoimmunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Increased susceptibility to organic dust exposure-induced inflammatory lung disease with enhanced rheumatoid arthritis-associated autoantigen expression in HLA-DR4 transgenic mice.Respiratory research · 2022Article
- Endothelial activation and injury by microparticles in patients with systemic lupus erythematosus and rheumatoid arthritis.Arthritis research & therapy · 2019Article
- Collective Genetic Interaction Effects and the Role of Antigen-Presenting Cells in Autoimmune Diseases.PloS one · 2017Article
- Human leukocyte Antigen-DM polymorphisms in autoimmune diseases.Open biology · 2016Review
- Article
- Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis.PloS one · 2016Article
- DRB1*0402 may influence arthritis by promoting naive CD4+ T-cell differentiation in to regulatory T cells.European journal of immunology · 2014Article
- Gender-biased regulation of human IL-17-producing cellsJournal of immune based therapies, vaccines and antimicrobials · 2013Article
- The autoimmune side of heart and lung diseases.Clinical reviews in allergy & immunology · 2013Review
- Antigen-specific gene therapy after immunisation reduces the severity of collagen-induced arthritis.Clinical & developmental immunology · 2013Article
- To B or not to B the conductor of rheumatoid arthritis orchestra.Clinical reviews in allergy & immunology · 2012Review
- Mincle and human B cell function.Journal of autoimmunity · 2012Article
- B cells as effectors and regulators of sex-biased arthritis.Autoimmunity · 2012Review
- Autoimmunity in 2011.Clinical reviews in allergy & immunology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Population studies have shown that amongst all the genetic factors linked with autoimmune disease development, MHC class II genes are the most significant. Experimental autoimmune arthritis resembling human rheumatoid arthritis (RA) can be induced in susceptible strains of mice following immunization with type II collagen (CIA). We generated transgenic mice lacking endogenous class II molecules and expressing various HLA genes including RA-associated, HLA-DRB1*0401 and HLA-DQ8, and RA-resistant, DRB1*0402, genes. The HLA molecules in these mice are expressed on the cell surface and can positively select CD4+ T cells expressing various Vβ T cell receptors. Endogenous class II invariant chain is required for proper functioning of the class II transgene. Arthritis development in transgenic mice is CD4+ and B cells dependent. Studies in humanized mice showed that B cells are required as antigen presenting cells in addition to antibody producing cells for the development of CIA. The transgenic mice expressing *0401 and *0401/DQ8 genes developed sex-biased arthritis with predominantly females being affected, similar to that of human RA. Further, the transgenic mice produced autoantibodies like rheumatoid factor and anti-cyclic antibodies. Antigen presentation by B cells leads to a sex-specific immune response in DRB1*0401 mice suggesting a role of B cells and HLA-DR in rendering susceptibility to develop arthritis in females.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.