ArticlePlacenta2011
How does variability of immune system genes affect placentation?
Article in Placenta, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- Altered Purinergic Signaling in Neurodevelopmental Disorders: Focus on P2 Receptors.Biomolecules · 2023Review
- Screening Candidate Genes Regulating Placental Development from Trophoblast Transcriptome at Early Pregnancy in Dazu Black Goats (Animals : an open access journal from MDPI · 2021Article
- All roads lead to inflammation: Is maternal immune activation a common culprit behind environmental factors impacting offspring neural control of breathing?Respiratory physiology & neurobiology · 2020Review
- Review
- Role of autophagy in Zika virus infection and pathogenesis.Virus research · 2018Review
- Extracellular vesicles generated by placental tissues ex vivo: A transport system for immune mediators and growth factors.American journal of reproductive immunology (New York, N.Y. : 1989) · 2018Article
- Endoplasmic Reticulum Aminopeptidase 2, a common immunological link to adverse pregnancy outcomes and cancer clearance?Placenta · 2017Review
- Intrauterine trophoblast migration: A comparative view of humans and rodents.Cell adhesion & migration · 2016Review
- The Residual Innate Lymphoid Cells in NFIL3-Deficient Mice Support Suboptimal Maternal Adaptations to Pregnancy.Frontiers in immunology · 2016Article
- Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus.Journal of visualized experiments : JoVE · 2015Article
- The role of the maternal immune system in the regulation of human birthweight.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Uterine NK cells: active regulators at the maternal-fetal interface.The Journal of clinical investigation · 2014Review
- Pathophysiology of ischemic placental disease.Seminars in perinatology · 2014Review
- MHC-dependent inhibition of uterine NK cells impedes fetal growth and decidual vascular remodelling.Nature communications · 2014Article
- Pathophysiology of hypertension in pre-eclampsia: a lesson in integrative physiology.Acta physiologica (Oxford, England) · 2013Review
- Killer cell immunoglobulin-like receptor gene associations with autoimmune and allergic diseases, recurrent spontaneous abortion, and neoplasms.Frontiers in immunology · 2013Article
- Article
- The role of the invasive, placental trophoblast in human pregnancy.Wiener medizinische Wochenschrift (1946) · 2012Review
- Review: Immunogenetics of human placentation.Placenta · 2012Review
- Genetics of recurrent miscarriage: challenges, current knowledge, future directions.Frontiers in genetics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Formation of the placenta is a crucial step in mammalian pregnancy. Apart from its function in ensuring an optimal supply of nutrients and oxygen to the fetus, the placenta is also the interface at which allo-recognition of invading trophoblast cells by the maternal immune system can potentially occur. We summarise here the "state of the art" on how variability of immune system genes that code for major histocompatibility complex (MHC) molecules and natural killer receptors (NKR) may impact on human placentation. MHC and NKR are the most polymorphic human genes. Our recent reports point out that specific combinations of fetal MHC and maternal NKR genes in humans correlate with the risk of pre-eclampsia, recurrent miscarriage (RM) and fetal growth restriction (FGR). Research in this field is still at an early stage and future studies in mouse and humans will be needed before the results can be translated to clinical applications. We discuss our recent work, as well as the opportunities offered by mouse genetics, to understand the cellular and molecular mechanisms underlying immune interactions at the maternal-fetal interface.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.