ArticleCancer cell2011
Oncogene-induced mitotic stress: p53 and pRb get mad too.
Article in Cancer cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- The novel selective inhibitors of cyclin-dependent kinase 4/6: in vitro and in silico study.Scientific reports · 2024Article
- The Aurora kinase B relocation blocker LXY18 triggers mitotic catastrophe selectively in malignant cells.PloS one · 2023Article
- Targeting CDK4/6 for Anticancer Therapy.Biomedicines · 2022Review
- Genomic Profiling Reveals the Molecular Landscape of Gastrointestinal Tract Cancers in Chinese Patients.Frontiers in genetics · 2021Article
- Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics.Nature communications · 2020Article
- Integrating the DNA damage and protein stress responses during cancer development and treatment.The Journal of pathology · 2018Review
- The microtubule-associated protein PRC1 is a potential therapeutic target for lung cancer.Oncotarget · 2018Article
- Overexpression of the E2F target geneOncotarget · 2017Article
- Chromosomal Instability in Gastric Cancer Biology.Neoplasia (New York, N.Y.) · 2017Review
- The Role of Aneuploidy in Cancer Evolution.Cold Spring Harbor perspectives in medicine · 2017Review
- Inhibition of Skp2 sensitizes lung cancer cells to paclitaxel.OncoTargets and therapy · 2017Article
- Article
- Orthogonal targeting of EGFRvIII expressing glioblastomas through simultaneous EGFR and PLK1 inhibition.Oncotarget · 2015Article
- A role of WT1 in cell division and genomic stability.Cell cycle (Georgetown, Tex.) · 2015Review
- A centrosomal route for cancer genome instability.Nature cell biology · 2014Article
- Targeting tumour-supportive cellular machineries in anticancer drug development.Nature reviews. Drug discovery · 2014Review
- Multi-layered cancer chromosomal instability phenotype.Frontiers in oncology · 2013Review
- The cancer biology of whole-chromosome instability.Oncogene · 2013Review
- Cancer cells preferentially lose small chromosomes.International journal of cancer · 2013Article
- Mitotic Stress and Chromosomal Instability in Cancer: The Case for TPX2.Genes & cancer · 2012Article
Corrections and comments
- Comment on
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oncogenic signaling frequently results in unscheduled overexpression of cell cycle proteins and replicative stress. In this issue of Cancer Cell, Schvartzman et al. show that inactivation of p53 or pRb induces Mad2, and the overexpression of this mitotic checkpoint protein is a necessary event during oncogene-induced mitotic stress.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.