ArticleDevelopmental cell2011
Dynamic coordination of innate immune signaling and insulin signaling regulates systemic responses to localized DNA damage.
Article in Developmental cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
- Bushen Huoxue decoction alleviates bisphenol a-induced infertility through the PMK-1 mitogen-activated protein kinases signaling pathway and downstream mitochondrial unfolded protein response inFrontiers in pharmacology · 2025Article
- DNA damage signaling ineLife · 2024Article
- Regulating metabolism to shape immune function: Lessons from Drosophila.Seminars in cell & developmental biology · 2023Review
- Transcriptome analysis of FOXO-dependent hypoxia gene expression identifies Hipk as a regulator of low oxygen tolerance in Drosophila.G3 (Bethesda, Md.) · 2022Article
- Suppression of intestinal dysfunction in a Drosophila model of Parkinson's disease is neuroprotective.Nature aging · 2022Article
- NO Synthesis in Immune-Challenged Locust Hemocytes and Potential Signaling to the CNS.Insects · 2021Article
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- Effects of Curcumin on Aging: Molecular Mechanisms and Experimental Evidence.BioMed research international · 2021Review
- Tolerance to Hypoxia Is Promoted by FOXO Regulation of the Innate Immunity Transcription Factor NF-κB/Relish inGenetics · 2020Article
- DNA damage responses in ageing.Open biology · 2019Review
- NF-κB Shapes Metabolic Adaptation by Attenuating Foxo-Mediated Lipolysis in Drosophila.Developmental cell · 2019Article
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- Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation.Aging cell · 2019Article
- Host-Microbe-Pathogen Interactions: A Review ofFrontiers in immunology · 2019Review
- Sexual Dimorphisms in Innate Immunity and Responses to Infection inFrontiers in immunology · 2019Review
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- A Complex Relationship between Immunity and Metabolism in Drosophila Diet-Induced Insulin Resistance.Molecular and cellular biology · 2018Article
- Genomic Instabilities, Cellular Senescence, and Aging:Frontiers in medicine · 2018Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Metazoans adapt to changing environmental conditions and to harmful challenges by attenuating growth and metabolic activities systemically. Recent studies in mice and flies indicate that endocrine signaling interactions between insulin/IGF signaling (IIS) and innate immune signaling pathways are critical for this adaptation, yet the temporal and spatial hierarchy of these signaling events remains elusive. Here, we identify and characterize a program of signaling interactions that regulates the systemic response of the Drosophila larva to localized DNA damage. We provide evidence that epidermal DNA damage induces an innate immune response that is kept in check by systemic repression of IIS activity. IIS repression induces NFκB/Relish signaling in the fat body, which is required for recovery of IIS activity in a second phase of the systemic response to DNA damage. This systemic response to localized DNA damage thus coordinates growth and metabolic activities across tissues, ensuring growth homeostasis and survival of the animal.
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