ArticleAnaerobe2011
In vivo lysogenization of a Clostridium difficile bacteriophage ФCD119.
Article in Anaerobe, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- The phi027 bacteriophage influences physiology and virulence of the lysogenic strain of Clostridioides difficile.Scientific reports · 2025Article
- Removal of mobile genetic elements from the genome ofFrontiers in microbiology · 2024Article
- The long and sinuous road to phage-based therapy ofFrontiers in medicine · 2023Review
- Diversity, Dynamics and Therapeutic Application ofViruses · 2022Review
- Potential Role of the Host-Derived Cell-Wall Binding Domain of Endolysin CD16/50L as a Molecular Anchor in Preservation of Uninfected Clostridioides difficile for New Rounds of Phage Infection.Microbiology spectrum · 2022Article
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- Clostridioides difficile phage biology and application.FEMS microbiology reviews · 2021Review
- Integrative Longitudinal Analysis of Metabolic Phenotype and Microbiota Changes During the Development of Obesity.Frontiers in cellular and infection microbiology · 2021Article
- Refining theMicroorganisms · 2020Article
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- Recent advances in the treatment ofInfection and drug resistance · 2019Article
- Bacteriophages are more virulent to bacteria with human cells than they are in bacterial culture; insights from HT-29 cells.Scientific reports · 2018Article
- Efficacy of an Optimised Bacteriophage Cocktail to Clear Clostridium difficile in a Batch Fermentation Model.Antibiotics (Basel, Switzerland) · 2018Article
- Bacteriophage Combinations Significantly Reduce Clostridium difficile Growth In Vitro and Proliferation In Vivo.Antimicrobial agents and chemotherapy · 2016Article
- 'Get in Early'; Biofilm and Wax Moth (Galleria mellonella) Models Reveal New Insights into the Therapeutic Potential of Clostridium difficile Bacteriophages.Frontiers in microbiology · 2016Article
- As Clear as Mud? Determining the Diversity and Prevalence of Prophages in the Draft Genomes of Estuarine Isolates of Clostridium difficile.Genome biology and evolution · 2015Article
- Clostridium difficile phages: still difficult?Frontiers in microbiology · 2014Review
- Article
- New treatment approaches forGut microbesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Clostridium difficile is a nosocomial pathogen identified as the cause of antibiotic-associated diarrhea and colitis. In this study, we have documented the lysogeny of a C. difficile bacteriophage in hamsters during C. difficile infection. The lysogens isolated from the hamsters were toxin typed and their phage integration site was confirmed by PCR. Through toxin ELISA it was found that the toxin production in the in vivo isolated lysogens was affected due to ФCD119 lysogenization as in the case of in vitro isolated ФCD119 lysogens. Together our findings indicate that a baceriophage can lysogenize its C. difficile host even during the infection process and highlights the importance of lysogeny of C. difficile phages as an evolutionary adaptation for survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.