ArticleHearing research2011
The adequate stimulus for mammalian linear vestibular evoked potentials (VsEPs).
Article in Hearing research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 93 citations in OpenAlex.
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- Type I hair cells of striolar and central zones in vestibular organs are essential for head stability and postural control.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Novel candidate genes for vestibular function identified through GWAS in the hybrid mouse diversity panel.BMC genomics · 2026Article
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- Subclinical auditory dysfunction in a genetic rat model of childhood absence epilepsy.Northern clinics of Istanbul · 2026Article
- ALZET pump implantation in mice for chronic drug delivery to the cochlea.Scientific reports · 2025Article
- An Integrated System for Comprehensive Mouse Peripheral Vestibular Function Evaluation Based on Vestibulo-ocular Reflex.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Functional contributions of quantal and non-quantal hair cell synaptic transmission in the vestibular periphery.bioRxiv : the preprint server for biology · 2025Article
- Otolith Irregular Fiber Stimulation Elicits a Rostro-Caudal Activity Gradient in the Vestibular Nuclear Complex and Both Direct and Indirect Afferent Pathways of the Vestibulocerebellum.The Journal of comparative neurology · 2025Article
- KbioRxiv : the preprint server for biology · 2025Article
- Noise-induced vestibular dysfunction in rats: longitudinal assessment using cVEMP and behavioral testing after low-frequency acoustic trauma.Frontiers in integrative neuroscience · 2025Article
- Instrumented swim test for quantifying motor impairment in rodents.Scientific reports · 2024Article
- Semicircular canal drug delivery safely targets the inner ear perilymphatic space.JCI insight · 2024Article
- Vestibular Testing-New Physiological Results for the Optimization of Clinical VEMP Stimuli.Audiology research · 2023Review
- Using macular velocity measurements to relate parameters of bone conduction to vestibular compound action potential responses.Scientific reports · 2023Article
- Noise-Induced Hearing Loss.Journal of clinical medicine · 2023Review
- A mathematical model for mechanical activation and compound action potential generation by the utricle in response to sound and vibration.Frontiers in neurology · 2023Article
- Function of bidirectional sensitivity in the otolith organs established by transcription factor Emx2.Nature communications · 2022Article
- A Single Fast Test for Semicircular Canal Dehiscence-oVEMP n10 to 4000 Hz-Depends on Stimulus Rise Time.Audiology research · 2022Article
- Transient peripheral vestibular hypofunction measured with vestibular short-latency evoked potentials following noise exposure in rats.Journal of neurophysiology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Short latency linear vestibular sensory evoked potentials (VsEPs) provide a means to objectively and directly assess the function of gravity receptors in mammals and birds. The importance of this functional measure is illustrated by its use in studies of the genetic basis of vestibular function and disease. Head motion is the stimulus for the VsEP. In the bird, it has been established that neurons mediating the linear VsEP respond collectively to the rate of change in linear acceleration during head movement (i.e. jerk) rather than peak acceleration. The kinematic element of motion responsible for triggering mammalian VsEPs has not been characterized in detail. Here we tested the hypothesis that jerk is the kinematic component of head motion responsible for VsEP characteristics. VsEP amplitudes and latencies changed systematically when peak acceleration level was held constant and jerk level was varied from ∼0.9-4.6 g/ms. In contrast, responses remained relatively constant when kinematic jerk was held constant and peak acceleration was varied from ∼0.9 to 5.5 g in mice and ∼0.44 to 2.75 g in rats. Thus the mammalian VsEP depends on jerk levels and not peak acceleration. We conclude that kinematic jerk is the adequate stimulus for the mammalian VsEP. This sheds light on the behavior of neurons generating the response. The results also provide the basis for standardizing the reporting of stimulus levels, which is key to ensuring that response characteristics reported in the literature by many laboratories can be effectively compared and interpreted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.