ArticleNeuroscience2011
Fear conditioning is associated with dynamic directed functional interactions between and within the human amygdala, hippocampus, and frontal lobe.
Article in Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03739645 (Physiological Studies in Healthy Subjects, Chronic Pain Patients and in Patients Undergoing Neurosurgical Procedures of Human Forebrain Mechanisms Mediating Somatic Sensation, Motor Control and Neurological Disorders), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Physiological Studies in Healthy Subjects, Chronic Pain Patients and in Patients Undergoing Neurosurgical Procedures of Human Forebrain Mechanisms Mediating Somatic Sensation, Motor Control and Neurological Disorders
Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Vasoactive intestinal polypeptide plasma levels associated with affective symptoms and brain structure and function in healthy females.Scientific reports · 2021Trial
- Aversively conditioned context enhances visual size illusion via stimulus-specific neural networks.iScience · 2025Article
- Modular segregation drives causality of the dynamic oscillatory network responses during threat processing.Brain communications · 2023Article
- Classically conditioned modulation of pain depends on stimulus intensity.Experimental brain research · 2022Article
- Behavioral, Physiological and EEG Activities Associated with Conditioned Fear as Sensors for Fear and Anxiety.Sensors (Basel, Switzerland) · 2020Review
- Oscillatory EEG activity induced by conditioning stimuli during fear conditioning reflects Salience and Valence of these stimuli more than Expectancy.Neuroscience · 2017Article
- Article
- Cross-frequency coupling in deep brain structures upon processing the painful sensory inputs.Neuroscience · 2015Article
- Postnatal TLR2 activation impairs learning and memory in adulthood.Brain, behavior, and immunity · 2015Article
- Painful cutaneous laser stimuli induce event-related gamma-band activity in the lateral thalamus of humans.Journal of neurophysiology · 2015Article
- Functional Connectivity of EEG Signals Under Laser Stimulation in Migraine.Frontiers in human neuroscience · 2015Article
- Aversive learning in adolescents: modulation by amygdala-prefrontal and amygdala-hippocampal connectivity and neuroticism.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- EEG analysis reveals widespread directed functional interactions related to a painful cutaneous laser stimulus.Journal of neurophysiology · 2013Article
- Article
- Article
- Studies of properties of "Pain Networks" as predictors of targets of stimulation for treatment of pain.Frontiers in integrative neuroscience · 2011Article
- A systematic review of the neurobiological aspects of memory in the aging process.Dementia & neuropsychologiaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The current model of fear conditioning suggests that it is mediated through modules involving the amygdala (AMY), hippocampus (HIP), and frontal lobe (FL). We now test the hypothesis that habituation and acquisition stages of a fear conditioning protocol are characterized by different event-related causal interactions (ERCs) within and between these modules. The protocol used the painful cutaneous laser as the unconditioned stimulus and ERC was estimated by analysis of local field potentials recorded through electrodes implanted for investigation of epilepsy. During the prestimulus interval of the habituation stage FL>AMY ERC interactions were common. For comparison, in the poststimulus interval of the habituation stage, only a subdivision of the FL (dorsolateral prefrontal cortex, dlPFC) still exerted the FL>AMY ERC interaction (dlFC>AMY). For a further comparison, during the poststimulus interval of the acquisition stage, the dlPFC>AMY interaction persisted and an AMY>FL interaction appeared. In addition to these ERC interactions between modules, the results also show ERC interactions within modules. During the poststimulus interval, HIP>HIP ERC interactions were more common during acquisition, and deep hippocampal contacts exerted causal interactions on superficial contacts, possibly explained by connectivity between the perihippocampal gyrus and the HIP. During the prestimulus interval of the habituation stage, AMY>AMY ERC interactions were commonly found, while interactions between the deep and superficial AMY (indirect pathway) were independent of intervals and stages. These results suggest that the network subserving fear includes distributed or widespread modules, some of which are themselves "local networks." ERC interactions between and within modules can be either static or change dynamically across intervals or stages of fear conditioning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.