Evidence map›Paper›PMID 21664185›Full record

ReviewTrends in immunology2011

Monocyte trafficking in acute and chronic inflammation.

Molly A Ingersoll, Andrew M Platt, Stephane Potteaux, Gwendalyn J Randolph

Abstract readReview
In one paragraph

Review in Trends in immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 187 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
187citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

187 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  16. Evaluation of peripheral blood inflammatory biomarkers in sickle cell disease with and without retinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024
    Article
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  18. Review
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127 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Molly A IngersollDepartment of Gene and Cell Medicine and the Immunology Institute, 1425 Madison Avenue, Mount Sinai School of Medicine, New York 10029, USA. mollyingersoll@gmail.com
Andrew M Platt
Stephane Potteaux
Gwendalyn J Randolph

Funding

Differentiation/migratory fate of monocyte-derived cellsR01AI049653 · NIAID · WASHINGTON UNIVERSITY · PI Gwendalyn J Randolph · 2000 to 2026
$4.6M
DIFFERENTIATION AND FUNCTION OF MONOCYTES AND MACROPHAGESR37AI049653 · NIAID · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J · 2016 to 2025
$4.3M
Pathways that regulate monocyte/dendritic cell migrationR01AI061741 · NIAID · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J · 2007 to 2011
$2.0M
Dendritic cell migration in atherosclerosisR01HL069446 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI RANDOLPH, GWENDALYN J · 2001 to 2004
$1.7M
Cholesterol and Lymphatic Transport of Molecules and CellsR01HL096539 · NHLBI · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J, SWARTZ, MELODY ANN · 2009 to 2012
$1.5M
Niacin-mediated migration of monocyte-derived cells in atherosclerosisF32HL096291 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI INGERSOLL, MOLLY ADELE · 2009 to 2010
$109k
NHLBI NIH HHS F32 HL096291NHLBI NIH HHS F32HL096291NHLBI NIH HHS HL096539NHLBI NIH HHS R01 HL069446NHLBI NIH HHS R01 HL096539NIAID NIH HHS AI049653NIAID NIH HHS AI061741NIAID NIH HHS R01 AI049653NIAID NIH HHS R01 AI061741NIAID NIH HHS R37 AI049653
6 · The paper itself

Abstract

Environmental signals at the site of inflammation mediate rapid monocyte mobilization and dictate differentiation programs whereby these cells give rise to macrophages or dendritic cells. Monocytes participate in tissue healing, clearance of pathogens and dead cells, and initiation of adaptive immunity. However, recruited monocytes can also contribute to the pathogenesis of infection and chronic inflammatory disease, such as atherosclerosis. Here, we explore monocyte trafficking in the context of acute inflammation, relying predominantly on data from microbial infection models. These mechanisms will be compared to monocyte trafficking during chronic inflammation in experimental models of atherosclerosis. Recent developments suggest that monocyte trafficking shares common themes in diverse inflammatory diseases; however, important differences exist between monocyte migratory pathways in acute and chronic inflammation.

Indexed as

Immunity, InnateAcute DiseaseAnimalsAtherosclerosisCell DifferentiationCell MovementChemokinesChronic DiseaseDendritic CellsHumansInflammationListeriaListeriosisMacrophagesMiceMonocytesChemokinesReceptors, Chemokine

Identifiers

PMID21664185
PMCPMC3179572

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.