Evidence map›Paper›PMID 21663897›Full record

ReviewCarbohydrate research2011

Expeditious oligosaccharide synthesis via selective, semi-orthogonal, and orthogonal activation.

Sophon Kaeothip, Alexei V Demchenko

Abstract readReview
In one paragraph

Review in Carbohydrate research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. HPLC-Based Automated Synthesis and Purification of Carbohydrates.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024
    Article
  4. Article
  5. Review
  6. Article
  7. Palladium(II)-assisted activation of thioglycosides.Organic & biomolecular chemistry · 2021
    Article
  8. Review
  9. Metal-free glycosylation with glycosyl fluorides in liquid SOBeilstein journal of organic chemistry · 2021
    Article
  10. Article
  11. Defining the Scope of the Acid-Catalyzed Glycosidation of Glycosyl Bromides.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020
    Article
  12. Review
  13. Article
  14. Intramolecular glycosylation.Beilstein journal of organic chemistry · 2017
    Review
  15. Glycosyltransferase engineering for carbohydrate synthesis.Biochemical Society transactions · 2016
    Review
  16. Beilstein journal of organic chemistry · 2016
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sophon KaeothipDepartment of Chemistry and Biochemistry, University of Missouri, St. Louis, One University Boulevard, St. Louis, MO 63121, USA.
Alexei V Demchenko

Funding

New strategies for expeditious oligosaccharide synthesisR15GM077170 · NIGMS · UNIVERSITY OF MISSOURI-ST. LOUIS · PI DEMCHENKO, ALEXEI V · 2006 to 2011
$748k
NIGMS NIH HHS GM077170NIGMS NIH HHS R15 GM077170
6 · The paper itself

Abstract

Traditional strategies for oligosaccharide synthesis often require extensive protecting and/or leaving group manipulations between each glycosylation step, thereby increasing the total number of synthetic steps while decreasing the efficiency of the synthesis. In contrast, expeditious strategies allow for the rapid chemical synthesis of complex carbohydrates by minimizing extraneous chemical manipulations. Oligosaccharide synthesis by selective activation of one leaving group over another is one such expeditious strategy. Herein, the significant improvements that have recently emerged in the area of the selective activation are discussed. The development of orthogonal strategy further expands the scope of the selective activation methodology. Surveyed in this article, are representative examples wherein these excellent innovations have been applied to the synthesis of various oligosaccharide sequences.

Indexed as

AcetalsAcylationCarbohydrate ConformationCarbohydrate SequenceChemistry, OrganicFluoridesGlycomicsGlycosidesGlycosylationHalogensHeparinImidoestersIonic LiquidsMolecular Sequence DataOligosaccharidesSulfoxidesAcetalsFluoridesGlycosidesHalogensHeparinImidoestersIonic LiquidsOligosaccharidesSulfoxidesThiocyanates

Identifiers

PMID21663897
PMCPMC3129461

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.