Evidence map›Paper›PMID 21663789›Full record

ReviewCell2011

The human brain in a dish: the promise of iPSC-derived neurons.

Ricardo Dolmetsch, Daniel H Geschwind

Abstract readReview
In one paragraph

Review in Cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 190 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
190citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

190 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Meta-Analysis IdentifiesInternational journal of molecular sciences · 2022
    Pooled it
  3. Mental health dished up-the use of iPSC models in neuropsychiatric research.Journal of neural transmission (Vienna, Austria : 1996) · 2020
    Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Neuron-reactive KIRNature communications · 2025
    Article
  11. A comprehensive guide to genomeZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
  12. Article
  13. Article
  14. Review
  15. A Comprehensive Review on Utilizing Human Brain Organoids to Study Neuroinflammation in Neurological Disorders.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
    Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Isolating Synaptic Vesicles from Neurospheres for Proteomics.Methods in molecular biology (Clifton, N.J.) · 2025
    Article

130 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ricardo DolmetschDepartment of Neurobiology, Fairchild Research Building, Room D227, Stanford University, Stanford, CA 94305, USA. ricardo.dolmetsch@stanford.edu
Daniel H Geschwind

Funding

A Comprehensive Approach to Identification of Autism Susceptibility GenesR01MH081754 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GESCHWIND, DANIEL H · 2008 to 2012
$14.6M
Using induced pluripotent stem cells to identify cellular phenotypes of autismDP1MH099904 · NIMH · STANFORD UNIVERSITY · PI DOLMETSCH, RICARDO E. · 2012 to 2012
$792k
NIMH NIH HHS DP1 MH099904NIMH NIH HHS R01 MH081754
6 · The paper itself

Abstract

Induced pluripotent stem cell-derived neurons from patients promise to fill an important niche between studies in humans and model organisms in deciphering mechanisms and identifying therapeutic avenues for neurologic and psychiatric diseases. Recent work begins to tap this potential and also highlights challenges that must be overcome to be fully realized.

Indexed as

AnimalsBrainBrain DiseasesHumansInduced Pluripotent Stem CellsMental DisordersNeurons

Identifiers

PMID21663789
PMCPMC3691069

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.