ReviewMolecular brain2011
Regulation of opioid receptor signalling: implications for the development of analgesic tolerance.
Review in Molecular brain, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Lipid profile dysregulation in opium users based on Fasa PERSIAN cohort study results.Scientific reports · 2021Trial
- The neural circuits and signalling pathways of opioid use disorder.Nature reviews. Neuroscience · 2025Review
- Genetic and epigenetic studies of opioid abuse disorder - the potential for future diagnostics.Expert review of molecular diagnostics · 2023Review
- Emotionality vs. Other Biobehavioural Traits: A Look at Neurochemical Biomarkers for Their Differentiation.Frontiers in psychology · 2021Review
- Functional Constructivism Approach to Multilevel Nature of Bio-Behavioral Diversity.Frontiers in psychiatry · 2021Review
- Vitamin D and Its Potential Interplay With Pain Signaling Pathways.Frontiers in immunology · 2020Review
- The Emerging Perspective of Morphine Tolerance: MicroRNAs.Pain research & management · 2019Review
- Functionality versus dimensionality in psychological taxonomies, and a puzzle of emotional valence.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Characterization of functional μ opioid receptor turnover in rat locus coeruleus: an electrophysiological and immunocytochemical study.British journal of pharmacology · 2017Article
- Benefits of Distinguishing between Physical and Social-Verbal Aspects of Behavior: An Example of Generalized Anxiety.Frontiers in psychology · 2016Article
- Kir3 channels undergo arrestin-dependant internalization following delta opioid receptor activation.Cellular and molecular life sciences : CMLS · 2015Article
- Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis.Journal of visualized experiments : JoVE · 2015Article
- Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking.British journal of pharmacology · 2015Article
- Morphine drives internal ribosome entry site-mediated hnRNP K translation in neurons through opioid receptor-dependent signaling.Nucleic acids research · 2014Article
- In vivo properties of KNT-127, a novel δ opioid receptor agonist: receptor internalization, antihyperalgesia and antidepressant effects in mice.British journal of pharmacology · 2014Article
- Imaging opioid analgesia in the human brain and its potential relevance for understanding opioid use in chronic pain.Neuropharmacology · 2014Review
- Ligand- and cell-dependent determinants of internalization and cAMP modulation by delta opioid receptor (DOR) agonists.Cellular and molecular life sciences : CMLS · 2014Article
- Endocytic profiles of δ-opioid receptor ligands determine the duration of rapid but not sustained cAMP responses.Molecular pharmacology · 2014Article
- Ligand-specific regulation of the endogenous mu-opioid receptor by chronic treatment with mu-opioid peptide agonists.BioMed research international · 2013Article
- Effects of perinatal oxycodone exposure on the cardiovascular response to acute stress in male rats at weaning and in young adulthood.Frontiers in physiology · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Opiate drugs are the most effective analgesics available but their clinical use is restricted by severe side effects. Some of these undesired actions appear after repeated administration and are related to adaptive changes directed at counteracting the consequences of sustained opioid receptor activation. Here we will discuss adaptations that contribute to the development of tolerance. The focus of the first part of the review is set on molecular mechanisms involved in the regulation of opioid receptor signalling in heterologous expression systems and neurons. In the second part we assess how adaptations that take place in vivo may contribute to analgesic tolerance developed during repeated opioid administration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.