ArticleLipids in health and disease2011
Rapeseed oil fortified with micronutrients reduces atherosclerosis risk factors in rats fed a high-fat diet.
Article in Lipids in health and disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Extraction, Isolation of Bioactive Compounds and Therapeutic Potential of Rapeseed (Molecules (Basel, Switzerland) · 2022Review
- The Therapeutic Role of Slit2 in Anti-fibrosis, Anti-inflammation and Anti-oxidative Stress in Rats with Coronary Heart Disease.Cardiovascular toxicology · 2021Article
- Comparative Metabolomic Analysis of Rapeseeds from Three Countries.Metabolites · 2019Article
- Antioxidant Enzyme Activities in Rabbits Under Oxidative Stress Induced By High Fat Diet.Journal of veterinary research · 2018Article
- Nutraceuticals as therapeutic agents for atherosclerosis.Biochimica et biophysica acta. Molecular basis of disease · 2018Review
- Rapeseed oil fortified with micronutrients can reduce glucose intolerance during a high fat challenge in rats.Nutrition & metabolism · 2018Article
- A Combination of Flaxseed Oil and Astaxanthin Improves Hepatic Lipid Accumulation and Reduces Oxidative Stress in High Fat-Diet Fed Rats.Nutrients · 2017Article
- Amelioration of oxidative and inflammatory status in hearts of cholesterol-fed rats supplemented with oils or oil-products with extra virgin olive oil components.European journal of nutrition · 2016Article
- Optimized Rapeseed Oils Rich in Endogenous Micronutrients Protect High Fat Diet Fed Rats from Hepatic Lipid Accumulation and Oxidative Stress.Nutrients · 2015Article
- Matrine pretreatment improves cardiac function in rats with diabetic cardiomyopathy via suppressing ROS/TLR-4 signaling pathway.Acta pharmacologica Sinica · 2015Article
- Effects of endogenous and exogenous micronutrients in rapeseed oils on the antioxidant status and lipid profile in high-fat fed rats.Lipids in health and disease · 2014Article
- Optimized rapeseed oils rich in endogenous micronutrients ameliorate risk factors of atherosclerosis in high fat diet fed rats.Lipids in health and disease · 2014Article
- A combination of flaxseed oil and astaxanthin alleviates atherosclerosis risk factors in high fat diet fed rats.Lipids in health and disease · 2014Article
- Antioxidant Effects of Spinach (Spinacia oleracea L.) Supplementation in Hyperlipidemic Rats.Preventive nutrition and food science · 2014Article
- Flaxseed oil and alpha-lipoic acid combination ameliorates hepatic oxidative stress and lipid accumulation in comparison to lard.Lipids in health and disease · 2013Article
- Micronutrients-fortified rapeseed oil improves hepatic lipid accumulation and oxidative stress in rats fed a high-fat diet.Lipids in health and disease · 2013Article
- Designer foods and their benefits: A review.Journal of food science and technology · 2013Review
- Flaxseed oil and α-lipoic acid combination reduces atherosclerosis risk factors in rats fed a high-fat diet.Lipids in health and disease · 2012Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicronutrients polyphenols, tocopherols and phytosterols in rapeseed exert potential benefit to cardiovascular system, but most of these micronutrients are removed by the refining process. The aim of this study was to determine the effect of rapeseed oil fortified with these micronutrients on the atherosclerosis risk factors in rats fed a high-fat diet.
methodsThe rodent diet contained 20% fat whose source was refined rapeseed oil (RRO) or fortified refined rapeseed oil with low, middle and high quantities of these micronutrients (L-, M- and H-FRRO). Forty male SD rats were divided into four groups. One group received RRO diet and other groups received L-, M- and H-FRRO diet for 10 weeks.
resultsMicronutrients supplementation significantly increased plasma antioxidant defense capacities, as evaluated by the significant elevation in the activities of GPx, CAT and SOD as well as the level of GSH, and the significant decline in lipid peroxidation. These micronutrients also reduced the plasma contents of TG, TC and LDL-C and increased the ratio of HDL-C/LDL-C. In addition, in parallel with the enhancement of these micronutrients, plasma levels of IL-6 and CRP declined remarkably.
conclusionRapeseed oil fortified with micronutrients polyphenols, tocopherols and phytosterols may contribute to prevent atherogenesis by ameliorating plasma oxidative stress, lipid profile and inflammation.
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