ArticleBMC musculoskeletal disorders2011
Bone turnover in passive smoking female rat: relationships to change in bone mineral density.
Article in BMC musculoskeletal disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Bone loss and increased bone marrow adiposity in ovary-intact and ovariectomized rats with chronic obstructive pulmonary disease.Journal of endocrinological investigation · 2025Article
- E-cigarette aerosol exposure effect on bone biomechanical properties in murine models.Journal of biomechanics · 2024Article
- AmbientEnvironmental health perspectives · 2023Article
- Review
- The Risk of Nonunion in Smokers Revisited: A Systematic Review and Meta-Analysis.Global spine journal · 2022Article
- Association between Serum Cotinine Levels and Bone Mineral Density: An Analysis of the National Health and Nutrition Examination Survey (NHANES).International journal of endocrinology · 2022Article
- Article
- The influence of LLLT applied on applied on calvarial defect in rats under effect of cigarette smoke.Journal of applied oral science : revista FOB · 2019Article
- Influence of Cigarette Smoke Inhalation on an Autogenous Onlay Bone Graft Area in Rats with Estrogen Deficiency: A Histomorphometric and Immunohistochemistry Study.International journal of molecular sciences · 2019Article
- The Effect of Tobacco Smoking on Bone Mass: An Overview of Pathophysiologic Mechanisms.Journal of osteoporosis · 2018Review
- Effects of long-term cigarette smoke exposure on bone metabolism, structure, and quality in a mouse model of emphysema.PloS one · 2018Article
- Musculoskeletal disorders in chronic obstructive pulmonary disease.BioMed research international · 2014Review
- Secondhand smoke exposure and osteoporosis in never-smoking postmenopausal women: the Fourth Korea National Health and Nutrition Examination Survey.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013Article
- Effect of epimedium pubescen flavonoid on bone mineral status and bone turnover in male rats chronically exposed to cigarette smoke.BMC musculoskeletal disorders · 2012Article
- Effects of palm vitamin e on bone-formation-related gene expression in nicotine-treated rats.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- THE INFLUENCE OF PASSIVE TOBACCO EXPOSURE AND PHYSICAL EXERCISE ON BONE TISSUE OF YOUNG RATS.Acta ortopedica brasileiraArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany studies have identified smoking as a risk factor for osteoporosis, but it is unclear whether passive smoking has an effect on bone mineral density and bone turnover and if such an effect could cause osteoporosis.The purpose of the study was to investigate the effect of passive smoking on bone mineral density (BMD) and bone turnover and the relationship between BMD and bone turnover in female rat.
methodsForty-eight female Wistar rats were randomized into six groups: 2-month, 3-month,4-month smoke-exposed rats and their controls. A rat model of passive cigarette smoking was prepared by breeding female rats in a cigarette-smoking box for 2, 3 or 4 months. Serums were analyzed for levels of osteocalcin, bone-specific alkaline phosphatase (b-ALP) and Tartrate-resistant acid phosphatase 5b (TRACP 5b). BMD was assessed at lumbar vertebrae and femur by dual energy X-ray absorptiometry in passive smoking rats and in control rats.
resultsBMD of lumbar spine and femur was lower in 4-month smoke-exposed female rats than that in controls. However, there was no significant difference in serum osteocalcin levels between smoke-exposed rats and controls. Significantly lower b-ALP and higher TRACP 5b were found in the 3-month or 4-month smoke-exposed rats compared to controls. Subsequent analysis showed that b-ALP positively correlated with BMD of the lumbar vertebrae(r = 0.764, P = 0.027) and femur(r = 0.899, P = 0.002) in 4-month smoke-exposed female rats. Furthermore, TRACP 5b levels negatively correlated with BMD of lumbar vertebrae (r = -0.871, P = 0.005) and femur (r = -0.715, P = 0.046) in 4-month smoke-exposed female rats.
conclusionOur data suggest that smoke exposure can inhibit bone formation and increase bone resorption. The hazardous effects of passive smoking on bone status are associated with increased bone turnover in female rat.
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