ArticleEuropean journal of immunology2011
Division of labor between subsets of lymph node dendritic cells determines the specificity of the CD8⁺ T-cell recall response to influenza infection.
Article in European journal of immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Single-cell analysis of pig lung leukocytes and their response to influenza infection and oseltamivir therapy.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Replication of Influenza A Virus in Secondary Lymphatic Tissue Contributes to Innate Immune Activation.Pathogens (Basel, Switzerland) · 2021Article
- Chronic Ethanol Consumption Reduces Existing CD8 T Cell Memory and Is Associated with Lesions in Protection against Secondary Influenza A Virus Infections.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Immunity to Respiratory Infection Is Reinforced Through Early Proliferation of Lymphoid TFrontiers in immunology · 2019Article
- Article
- Monocyte-derived dendritic cells enhance protection against secondary influenza challenge by controlling the switch in CD8European journal of immunology · 2017Article
- Environmental cues orchestrate regional immune surveillance and protection by pulmonary CTLs.Journal of leukocyte biology · 2016Review
- PB1 as a potential target for increasing the breadth of T-cell mediated immunity to Influenza A.Scientific reports · 2016Article
- Smad4 promotes differentiation of effector and circulating memory CD8 T cells but is dispensable for tissue-resident memory CD8 T cells.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Antigen signal strength during priming determines effector CD4 T cell function and antigen sensitivity during influenza virus challenge.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Quantitative and qualitative deficits in neonatal lung-migratory dendritic cells impact the generation of the CD8+ T cell response.PLoS pathogens · 2014Article
- Lung-resident memory CD8 T cells (TRM) are indispensable for optimal cross-protection against pulmonary virus infection.Journal of leukocyte biology · 2014Article
- Viral infection of the lung: host response and sequelae.The Journal of allergy and clinical immunology · 2013Review
- Splenic priming of virus-specific CD8 T cells following influenza virus infection.Journal of virology · 2013Article
- Antigen and transforming growth factor Beta receptors contribute to long term functional and phenotypic heterogeneity of memory CD8 T cells.Frontiers in immunology · 2013Article
- Dendritic cells and influenza A virus infection.Virulence · 2012Review
- Duration of antigen availability influences the expansion and memory differentiation of T cells.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Cytotoxic T lymphocytes (CTLs) are important targets for vaccines against a wide variety of infections that enter the body via mucosal tissues. To induce effective immunity these vaccines must include the most protective epitopes and elicit rapid recall responses at the site of infection. Although live attenuated viruses are sometimes used to induce cellular immunity against recurrent influenza infections, the mechanisms that determine the magnitude of the response to individual viral components are very poorly defined. Heterosubtypic infections in C57BL/6 mice illustrate an additional level of complexity, when the antigen specificity of the response shifts dramatically between primary and secondary challenge. This model provides a unique opportunity to identify the mechanisms that regulate memory CD8(+) T-cell reactivation in vivo and control the specificity of the recall response by pathogen-specific CTL. We show that multiple factors contribute to the changing pattern of immunodominance during secondary infection, including the location of the memory CD8(+) T cells at the time of reinfection and their ability to directly recognize migratory CD103(+) DCs as they arrive in the lung draining LN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.