ArticleMethods in molecular biology (Clifton, N.J.)2011
Supported lipid bilayers and DNA curtains for high-throughput single-molecule studies.
Article in Methods in molecular biology (Clifton, N.J.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Single-molecule DNA flow-stretch assays for high-throughput DNA-protein interaction studies.FEBS open bio · 2026Article
- Single-molecule DNA-flow stretching assay as a versatile hybrid tool for investigating DNA-protein interactions.BMB reports · 2025Review
- Rapid Long-distance Migration of RPA on Single Stranded DNA Occurs Through Intersegmental Transfer Utilizing Multivalent Interactions.Journal of molecular biology · 2024Article
- Biochemistry: one molecule at a time.Essays in biochemistry · 2021Article
- DNA Manipulation and Single-Molecule Imaging.Molecules (Basel, Switzerland) · 2021Review
- A theoretical analysis of single molecule protein sequencing via weak binding spectra.PloS one · 2019Article
- Assembling the Human Resectosome on DNA Curtains.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Efficient modification of λ-DNA substrates for single-molecule studies.Scientific reports · 2017Article
- Inserting Extrahelical Structures into Long DNA Substrates for Single-Molecule Studies of DNA Mismatch Repair.Methods in enzymology · 2017Article
- Next-Generation DNA Curtains for Single-Molecule Studies of Homologous Recombination.Methods in enzymology · 2017Article
- Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- High-Throughput Universal DNA Curtain Arrays for Single-Molecule Fluorescence Imaging.Langmuir : the ACS journal of surfaces and colloids · 2015Article
- High-throughput single-molecule studies of protein-DNA interactions.FEBS letters · 2014Review
- Visualizing protein movement on DNA at the single-molecule level using DNA curtains.DNA repair · 2014Review
- Mechanical operation and intersubunit coordination of ring-shaped molecular motors: insights from single-molecule studies.Biophysical journal · 2014Article
- Surface passivation for single-molecule protein studies.Journal of visualized experiments : JoVE · 2014Article
- DNA dynamics and single-molecule biology.Chemical reviews · 2014Review
- Towards physiological complexity with in vitro single-molecule biophysics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Molecular traffic jams on DNA.Annual review of biophysics · 2013Review
- High-throughput single-molecule analysis of DNA-protein interactions by tethered particle motion.Nucleic acids research · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Single-molecule studies of protein-DNA interactions continue to yield new information on numerous DNA processing pathways. For example, optical microscopy-based techniques permit the real-time observation of proteins that interact with DNA substrates, which in turn allows direct insight into reaction mechanisms. However, these experiments remain technically challenging and are limited by the paucity of stable chromophores and the difficulty of acquiring statistically significant observations. In this protocol, we describe a novel, high-throughput, nanofabricated experimental platform enabling real-time imaging of hundreds of individual protein-DNA complexes over hour timescales.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.