ArticleMethods in molecular biology (Clifton, N.J.)2011
Isolation of meiotic recombinants from mouse sperm.
Article in Methods in molecular biology (Clifton, N.J.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed.
- Argonaute proteins orchestrate Meiotic Sex Chromosome Inactivation and timing of the spermatogenic transcriptional program.PLoS genetics · 2026Article
- Article
- Genetic dissection of crossover mutants defines discrete intermediates in mouse meiosis.Molecular cell · 2023Article
- Article
- Split versions of Cleave and Rescue selfish genetic elements for measured self limiting gene drive.PLoS genetics · 2021Article
- Mechanistic Insight into Crossing over during Mouse Meiosis.Molecular cell · 2020Article
- Article
- Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance.PLoS genetics · 2017Article
- Local and sex-specific biases in crossover vs. noncrossover outcomes at meiotic recombination hot spots in mice.Genes & development · 2015Article
- Mouse tetrad analysis provides insights into recombination mechanisms and hotspot evolutionary dynamics.Nature genetics · 2014Article
- Contrasted patterns of crossover and non-crossover at Arabidopsis thaliana meiotic recombination hotspots.PLoS genetics · 2013Article
- Preaching about the converted: how meiotic gene conversion influences genomic diversity.Annals of the New York Academy of Sciences · 2012Review
- Comprehensive, fine-scale dissection of homologous recombination outcomes at a hot spot in mouse meiosis.Molecular cell · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Homologous recombination during meiosis is critical for the formation of gametes. Recombination is initiated by programmed DNA double-strand breaks which preferentially occur at hotspots dispersed throughout the genome. These double-strand breaks are repaired from the homolog, resulting in either a crossover or noncrossover product. Multiple noncrossover events are required for homolog pairing, and at least one crossover is critical for proper chromosome segregation at the first meiotic division. Consequently, homologous recombination in meiosis occurs at high frequencies. This chapter describes how to characterize crossovers and noncrossovers at a hotspot in mice using allele-specific PCR. Amplification of recombinant products directly from sperm DNA is a powerful approach to determine recombination frequencies and map recombination breakpoints, providing insight into homologous recombination mechanisms.
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