ReviewAdvances in experimental medicine and biology2011
Cathepsin proteases in Toxoplasma gondii.
Review in Advances in experimental medicine and biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Transient Adaptation ofInternational journal of molecular sciences · 2024Article
- The Toxoplasma plant-like vacuolar compartment (PLVAC).The Journal of eukaryotic microbiology · 2022Review
- Host-Parasite Interaction of Atlantic salmon (Frontiers in immunology · 2021Article
- Discovery and Optimization of Triazine Nitrile Inhibitors ofACS chemical neuroscience · 2020Article
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- iTRAQ-Based Comparative Proteomic Analysis of AdultFrontiers in microbiology · 2018Article
- DNA Vaccines Encoding Toxoplasma gondii Cathepsin C 1 Induce Protection against Toxoplasmosis in Mice.The Korean journal of parasitology · 2017Article
- Protection via a ROM4 DNA vaccine and peptide against Toxoplasma gondii in BALB/c mice.BMC infectious diseases · 2017Article
- Identification and characterization of a cathepsin L-like cysteine protease from Rhipicephalus (Boophilus) annulatus.Experimental & applied acarology · 2016Article
- Secretion of Polypeptide Crystals from Tetrahymena thermophila Secretory Organelles (Mucocysts) Depends on Processing by a Cysteine Cathepsin, Cth4p.Eukaryotic cell · 2015Article
- Identification and characterization of a cathepsin-L-like peptidase in Eimeria tenella.Parasitology research · 2014Article
- Characterization of the chloroquine resistance transporter homologue in Toxoplasma gondii.Eukaryotic cell · 2014Article
- An aspartyl cathepsin, CTH3, is essential for proprotein processing during secretory granule maturation in Tetrahymena thermophila.Molecular biology of the cell · 2014Article
- Article
- Inflammasome sensor NLRP1 controls rat macrophage susceptibility to Toxoplasma gondii.PLoS pathogens · 2014Article
- Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii.mBio · 2014Article
- Identification and characterization of Toxoplasma gondii aspartic protease 1 as a novel vaccine candidate against toxoplasmosis.Parasites & vectors · 2013Article
- Toxoplasma gondii cathepsin proteases are undeveloped prominent vaccine antigens against toxoplasmosis.BMC infectious diseases · 2013Article
- Non-canonical maturation of two papain-family proteases in Toxoplasma gondii.The Journal of biological chemistry · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cysteine proteases are important for the growth and survival of apicomplexan parasites that infect humans. The apicomplexan Toxoplasma gondii expresses five members of the C1 family of cysteine proteases, including one cathepsin L-like (TgCPL), one cathepsin B-like (TgCPB) and three cathepsin C-like (TgCPC1, 2 and 3) proteases. Recent genetic, biochemical and structural studies reveal that cathepsins function in microneme and rhoptry protein maturation, host cell invasion, replication and nutrient acquisition. here, we review the key features and roles of T. gondii cathepsins and discuss the therapeutic potential for specific inhibitor development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.