ReviewHuman genetics2011
A scaffold for X chromosome inactivation.
Review in Human genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Multiple distinct domains of human XIST are required to coordinate gene silencing and subsequent heterochromatin formation.Epigenetics & chromatin · 2022Article
- Independent domains for recruitment of PRC1 and PRC2 by human XIST.PLoS genetics · 2021Article
- Architectural RNA in chromatin organization.Biochemical Society transactions · 2020Review
- Progress in Delivery of siRNA-Based Therapeutics Employing Nano-Vehicles for Treatment of Prostate Cancer.Bioengineering (Basel, Switzerland) · 2020Review
- Inhibition of prostate cancer DU145 cell growth with small interfering RNA targeting the SATB1 gene.Experimental and therapeutic medicine · 2018Article
- Review
- Linking RNA biology to lncRNAs.Genome research · 2015Review
- Xist localization and function: new insights from multiple levels.Genome biology · 2015Review
- miR-23a suppresses proliferation of osteosarcoma cells by targeting SATB1.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Silencing SATB1 inhibits the malignant phenotype and increases sensitivity of human osteosarcoma U2OS cells to arsenic trioxide.International journal of medical sciences · 2014Article
- Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci.Epigenetics & chromatin · 2014Article
- Guided by RNAs: X-inactivation as a model for lncRNA function.Journal of molecular biology · 2013Review
- The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome.Science (New York, N.Y.) · 2013Article
- Silencing SATB1 inhibits proliferation of human osteosarcoma U2OS cells.Molecular and cellular biochemistry · 2013Article
- Charity begins at home: non-coding RNA functions in DNA repair.Nature reviews. Molecular cell biology · 2013Review
- X-inactivation: quantitative predictions of protein interactions in the Xist network.Nucleic acids research · 2013Article
- HERV-H RNA is abundant in human embryonic stem cells and a precise marker for pluripotency.Retrovirology · 2012Article
- Article
- Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing.The Journal of biological chemistry · 2012Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
X chromosome inactivation (XCI), the silencing of one of the two X chromosomes in XX female cells, equalises the dosage of X-linked genes relative to XY males. The process is mediated by the non-coding RNA X inactive specific transcript (Xist) that binds in cis and propagates along the inactive X chromosome elect, triggering chromosome-wide silencing. The mechanisms by which Xist RNA binds and spreads along the chromosome, and initiates Xist-mediated chromosome silencing remain poorly understood. Accumulating evidence suggests that chromosome and nuclear organisation are important in both processes. Notably, recent studies have identified specific factors, previously shown to be components of the nuclear matrix or scaffold, to play a role both in Xist RNA-binding and in Xist-mediated silencing. In this review we provide a perspective on these studies in the context of previous work on chromosome/nuclear architecture in XCI.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.