SynthesisThe journal of headache and pain2011
Migraine and restless legs syndrome: is there an association?
Synthesis in The journal of headache and pain, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Migraine and Restless Legs Syndrome: A Meta-Analysis.Journal of sleep research · 2026Pooled it
- Migraine and restless legs syndrome in women.Cephalalgia : an international journal of headache · 2012Trial
- Dopaminergic Dysregulation in Migraine: From Hypothalamic A11 Dysfunction to a Systemic Biobehavioral Phenotype.International journal of molecular sciences · 2026Review
- Restless Legs Syndrome and Neurological Comorbidities: A Narrative Review.Journal of clinical medicine · 2026Review
- Mechanistic Overlaps Between Sleep and Headache Disorders: From Dopaminergic Dysfunction to Neuroinflammation-A Narrative Review.Clocks & sleep · 2026Review
- The clinical implications of the comorbidity between restless legs syndrome and migraines.Sleep and biological rhythms · 2025Article
- Associations between the burdens of comorbid sleep problems, central sensitization, and headache-related disability in patients with migraine.Frontiers in neurology · 2024Article
- Central sensitization in migraine is related to restless legs syndrome.Journal of neurology · 2021Article
- Episodic Migraine Comorbidities: Avoiding Pitfalls and Taking Therapeutic Opportunities.Current pain and headache reports · 2019Review
- Patterns of gray matter alterations in migraine and restless legs syndrome.Annals of clinical and translational neurology · 2019Article
- Accompanying migrainous features in pediatric migraine patients with restless legs syndrome.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Article
- Relationship between primary restless legs syndrome and migraine with aura.The Kaohsiung journal of medical sciences · 2016Article
- Increased Risk of Restless Legs Syndrome in Patients With Migraine: A Nationwide Population-Based Cohort Study.Medicine · 2016Article
- Risk of Restless Legs Syndrome Following Tension-Type Headache: A Nationwide Population-Based Cohort Study.Medicine · 2015Observational
- Does pramipexole treatment improve headache in patients with concomitant migraine and restless legs syndrome?Tremor and other hyperkinetic movements (New York, N.Y.) · 2013Article
- Migraine and restless legs syndrome in men.Cephalalgia : an international journal of headache · 2013Article
- Comorbidity in perimenstrual migraine.Current pain and headache reports · 2012Review
- Primary headaches in restless legs syndrome patients.Annals of Indian Academy of Neurology · 2012Article
- Migraine: risk factor and comorbidity.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2012Article
- Migraine and movement disorders.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Occasional clinical reports have suggested a link between migraine and restless legs syndrome. We undertook a systematic review of the evidence, which supports this association, and consider possible shared pathogenic mechanisms and the implications for current clinical practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.