ArticlePathology research international2011
Serrated polyposis: an enigmatic model of colorectal cancer predisposition.
Article in Pathology research international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes.The American journal of gastroenterology · 2015Guideline
- Inherited BRCA1 and RNF43 pathogenic variants in a familial colorectal cancer type X family.Familial cancer · 2024Article
- Clinical characteristics of patients with serrated polyposis syndrome in Korea: comparison with Western patients.Intestinal research · 2017Article
- Findings in young adults at colonoscopy from a hospital service database audit.BMC gastroenterology · 2017Article
- Serrated Polyps and Serrated Polyposis Syndrome.Clinics in colon and rectal surgery · 2016Review
- Serrated polyposis associated with a family history of colorectal cancer and/or polyps: The preferential location of polyps in the colon and rectum defines two molecular entities.International journal of molecular medicine · 2016Article
- Type 1 serrated polyposis represents a predominantly female disease with a high prevalence of dysplastic serrated adenomas, without germline mutation in MUTYH, APC, and PTEN genes.United European gastroenterology journal · 2016Article
- Endoscopic and histologic characteristics of serrated lesions.World journal of gastroenterology · 2015Review
- Clinicopathologic Significance of BRAF Mutation and Extracellular Signal Regulated Kinase 1/2 Expression in Patients With a Colorectal Adenocarcinoma.Annals of coloproctology · 2015Article
- Germline mutations in oncogene-induced senescence pathways are associated with multiple sessile serrated adenomas.Gastroenterology · 2014Article
- Serrated polyposis: colonic phenotype, extracolonic features, and familial risk in a large cohort.Diseases of the colon and rectum · 2013Article
- Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management.Journal of gastroenterology · 2013Review
- Multiplicity and molecular heterogeneity of colorectal carcinomas in individuals with serrated polyposis.The American journal of surgical pathology · 2013Article
- Article
- Phenotype and polyp landscape in serrated polyposis syndrome: a series of 100 patients from genetics clinics.The American journal of surgical pathology · 2012Article
- ERK/pERK expression and B-raf mutations in colon adenocarcinomas: correlation with clinicopathological characteristics.World journal of surgical oncology · 2012Article
- Management of Patients with Hereditary Colorectal Cancer Syndromes.GE Portuguese journal of gastroenterologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Serrated polyposis has only recently been accepted as a condition which carries an increased personal and familial risk of colorectal cancer. Described over four decades ago, it remains one of the most underrecognized and poorly understood of all the intestinal polyposes. With a variety of phenotypic presentations, it is likely that serrated polyposis represents a group of diseases rather than a single entity. Further, neoplastic progression in serrated polyposis may be associated with premature aging in the normal mucosa, typified by widespread gene promoter hypermethylation. From this epigenetically altered field, arise diverse polyps and cancers which show a range of molecular features. Despite a high serrated polyp count, only one-third of colorectal cancers demonstrate a BRAF V600E mutation, the molecular hallmark of the canonical serrated pathway, suggesting that though multiple serrated polyps act as a marker of an abnormal mucosa, the majority of CRC in these patients arise within lesions other than BRAF-mutated serrated polyps.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.