ArticlePersonalized medicine2011
Genotype-environment interactions and their translational implications.
Article in Personalized medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Yield stability of groundnut genotypes across contrasting environments in Niger using GGE biplot analysis.Scientific reports · 2026Article
- Genotype × environment interaction insights for yield and yield components in castor via AMMI and GGE biplot models.Scientific reports · 2026Article
- GEiPRS: a fast and powerful machine learning method for polygenic risk score prediction by leveraging genotype-environment interactions.Briefings in bioinformatics · 2026Article
- Yield stability of finger millet genotypes assessed by AMMI and GGE biplot analysis across diverse environments.Scientific reports · 2025Article
- Leveraging Automated Machine Learning for Environmental Data-Driven Genetic Analysis and Genomic Prediction in Maize Hybrids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Multi-omics approaches for understanding gene-environment interactions in noncommunicable diseases: techniques, translation, and equity issues.Human genomics · 2025Review
- Regulation of Airway Epithelial-Derived Alarmins in Asthma: Perspectives for Therapeutic Targets.Biomedicines · 2024Review
- Genomics and Bioinformatics in One Health: Transdisciplinary Approaches for Health Promotion and Disease Prevention.International journal of environmental research and public health · 2024Article
- Evaluating significance of European-associated index SNPs in the East Asian population for 31 complex phenotypes.BMC genomics · 2023Article
- Similarity and diversity of genetic architecture for complex traits between East Asian and European populations.BMC genomics · 2023Article
- Neural crest E-cadherin loss drives cleft lip/palate by epigenetic modulation via pro-inflammatory gene-environment interaction.Nature communications · 2023Article
- Modeling the influence of phenotypic plasticity on maize hybrid performance.Plant communications · 2023Article
- Heterogeneity Assessment of Kenaf Breeding Field through Spatial Dependence Analysis on Crop Growth Status Map Derived by Unmanned Aerial Vehicle.Plants (Basel, Switzerland) · 2023Article
- Current State of Modeling Human Psychiatric Disorders Using Zebrafish.International journal of molecular sciences · 2023Review
- Detecting associated genes for complex traits shared across East Asian and European populations under the framework of composite null hypothesis testing.Journal of translational medicine · 2022Article
- QTL Mapping for Haploid Inducibility Using Genotyping by Sequencing in Maize.Plants (Basel, Switzerland) · 2022Article
- Flavor and Other Quality Traits of Tomato Cultivars Bred for Diverse Production Systems as Revealed in Organic Low-Input Management.Frontiers in nutrition · 2022Article
- Expression of DLX6 Gene in Mandibular Deficiency (Retrognathic Mandible): A Randomized Clinical and Genetic Study.Cureus · 2021Article
- Locally Adapted and Organically Grown Landrace and Ancient Spring Cereals-A Unique Source of Minerals in the Human Diet.Foods (Basel, Switzerland) · 2021Article
- Gene-environment interactions in Alzheimer's disease: A potential path to precision medicine.Pharmacology & therapeutics · 2019Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Organisms frequently encounter different environmental conditions. The physiological and behavioral responses to these conditions depend on the genetic make up of individuals. Genotype generally remains constant from one environment to another, although occasional spontaneous mutations may occur which cause it to change. However, when the same genotype is subjected to different environments, it can produce a wide range of phenotypes. These phenotypic variations are attributable to the effect of the environment on the expression and function of genes influencing the trait. Changes in the relative performance of genotypes across different environments are referred to as genotype-environment interactions (GEI). A general argument for research on the impact of GEI in common diseases is that it provides insights into disease processes at the population, individual and molecular levels. In humans, GEI is complicated by multiple factors including phenocopies, genocopies, epigenetics and imprinting. A better understanding of GEI is essential if patients are to make informed health choices guided by their genomic information. In this article, we clarify the role of the environment on phenotype, we describe how human population structure can obscure the resolution of GEI and we discuss how emerging biobanks across the globe can be coordinated to further our understanding of genotype-phenotype associations within the context of varying environment.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.