ArticleMikrochimica acta2011
Development of an SPR imaging biosensor for determination of cathepsin G in saliva and white blood cells.
Article in Mikrochimica acta, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 26 citations in OpenAlex.
- Review
- Carboxymethyl Dextran-Based Biosensor for Simultaneous Determination of IDO-1 and IFN-Gamma in Biological Material.Biosensors · 2025Article
- Photonics of human saliva: potential optical methods for the screening of abnormal health conditions and infections.Biophysical reviews · 2021Review
- Non-Invasive Electrochemical Biosensors Operating in Human Physiological Fluids.Sensors (Basel, Switzerland) · 2020Review
- Cathepsin D serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging.Oncology letters · 2014Article
- Extracellular proteolysis of apolipoprotein E (apoE) by secreted serine neuronal protease.PloS one · 2014Article
- Synthesis and Biological Activity ofInternational journal of peptide research and therapeutics · 2013Article
- SPR imaging biosensor for the 20S proteasome: sensor development and application to measurement of proteasomes in human blood plasma.Mikrochimica acta · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cathepsin G (CatG) is an endopeptidase that is associated with the early immune response. The synthetic compound cathepsin G inhibitor I (CGI-I) was tested for its ability to inhibit the activity of CatG via a new surface plasmon resonance imaging assay. CGI-I was immobilized on the gold surface of an SPR sensor that was first modified with 1-octadecanethiol. A concentration of CGI-I equal to 4.0 μg·mL-1 and a pH of 8.0 were found to give the best results. The dynamic response of the sensor ranges from 0.25 to 1.5 ng·mL-1, and the detection limit is 0.12 ng·mL-1. The sensor was applied to detect CatG in human saliva and white blood cells.FigureThe synthetic compound cathepsin G inhibitor I (CGI-I) was tested for its ability to inhibit the activity of cathepsin G via a newly developed surface plasmon resonance imaging assay. The sensor was applied to detect cathepsin G in human saliva and white blood cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.