ArticleMedicine and science in sports and exercise2012
Attenuated inheritance of body weight by running in monozygotic twins.
Article in Medicine and science in sports and exercise, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeGenetic factors account for 40%-70% of the population variation in body mass index (BMI), suggesting that genetic predisposition is a major risk factor for excess weight. The purpose of this study was to test whether exercise attenuates the inherited risk for excess body weight.
methodsSurvey questionnaires of exercise (usual running distance) and BMI were obtained from a national sample of 582 female and 344 male self-identified monozygotic (MZ) twins. Regression analyses were used to test whether running disparity diminished the inheritance of BMI when adjusted for age, education, cigarette use, and selected dietary variables.
resultsThe active twins ran between 0 and 10.7 km · d(-1) more than their less active twins if female (mean ± SD = 1.61 ± 1.50 km · d(-1)) and between 0 and 13.7 km · d(-1) more if male (1.88 ± 1.78 km · d(-1)). Average BMIs of the less active twins were 22.38 ± 3.56 and 24.59 ± 3.08 kg · m(-2) in females and males, respectively. Within-twin correlations were significant (P < 0.0001) for usual distance run (females: r = 0.64; males: r = 0.61) and BMI (females: r = 0.67; males: r = 0.71). Greater running differences (Δkm · d(-1)) attenuated the effect of the less active twins' BMIs on their active MZ twins' BMI (females: -14.3% per Δkm · d(-1), P < 10(-7); males: -7.4% per Δkm · d(-1), P = 0.004), such that by 4 Δkm · d(-1), the inherited risk was reduced by 58.8% in females and 29.6% in males.
conclusionsThese results are consistent with the attenuation of the inherited risk of excess body weight by running, which is remarkable because BMI regulation is assumed to be multifactorial, its genetic inheritance is polygenic, and no single genetic polymorphism currently explains >1% of the BMI variance.
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