ReviewCurrent opinion in anaesthesiology2011
Anesthetic modulation of neuroinflammation in Alzheimer's disease.
Review in Current opinion in anaesthesiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Desoxyrhapontigenin attenuates neuronal apoptosis in an isoflurane-induced neuronal injury model by modulating the TLR-4/cyclin B1/Sirt-1 pathway.AMB Express · 2020Article
- Anesthetic Alterations of Collective Terahertz Oscillations in Tubulin Correlate with Clinical Potency: Implications for Anesthetic Action and Post-Operative Cognitive Dysfunction.Scientific reports · 2017Article
- The effect of local anesthetic on pro-inflammatory macrophage modulation by mesenchymal stromal cells.International immunopharmacology · 2016Article
- Exposure to general anesthesia and the risk of dementia.Journal of pain research · 2015Review
- Non-neurological surgery and cerebrospinal fluid biomarkers for neuronal and astroglial integrity.Journal of neural transmission (Vienna, Austria : 1996) · 2014Article
- Cerebral dysfunction after coronary artery bypass surgery.Journal of anesthesia · 2014Review
- Comparison of neurodegeneration and cognitive impairment in neonatal mice exposed to propofol or isoflurane.PloS one · 2014Article
- Gender-specific differences in the central nervous system's response to anesthesia.Translational stroke research · 2013Review
- Volatile anesthetics-induced neuroinflammatory and anti-inflammatory responses.Medical gas research · 2013Article
- Direct modulation of microtubule stability contributes to anthracene general anesthesia.Journal of the American Chemical Society · 2013Article
- The neuroinflammatory response of postoperative cognitive decline.British medical bulletin · 2013Review
- Article
- Effects of combined ketamine/xylazine anesthesia on light induced retinal degeneration in rats.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewTo summarize key studies and recent thought on the role of neuroinflammation in chronic neurodegeneration, and whether it can be modulated by anesthesia and surgery. RECENT
findingsA large and growing body of evidence shows that neuroinflammation participates in the development of neurodegeneration associated with Alzheimer's disease. Modulation may be possible early in the pathogenesis, and less so when cognitive symptoms appear. A dysfunctional hypoinflammatory response may permit accelerated damage due to other mechanisms in late disease. The peripheral inflammatory response elicited by surgery itself appears to provoke a muted neuroinflammatory response, which enhances ongoing neurodegeneration in some models. Anesthetics have both anti-inflammatory and proinflammatory effects depending on the drug and concentration, but in general, appear to play a small role in neuroinflammation. Human studies at the intersection of chronic neurodegeneration, neuroinflammation, and surgery/anesthesia are rare. SUMMARY: The perioperative period has the potential to modulate the progression of chronic neurodegenerative diseases. The growing number of elderly having surgery, combined with the expanding life expectancy, indicates the potential for this interaction to have considerable public health implications, and call for further research, especially in humans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.