ArticleThe Journal of biological chemistry2011
High glucose-treated macrophages augment E-selectin expression in endothelial cells.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Cytokine profiling in patients with polypoidal choroidal vasculopathy before and after intravitreal injection of ranibizumab.American journal of translational research · 2022Article
- Clinical Importance of FNDC-5 and Selectin-E mRNA Expression Among Type 2 Diabetics with and without Obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- High glucose-induced oxidative stress impairs proliferation and migration of human gingival fibroblasts.PloS one · 2018Article
- Emerging role of chemokine CC motif ligand 4 related mechanisms in diabetes mellitus and cardiovascular disease: friends or foes?Cardiovascular diabetology · 2016Review
- Long-term antihypertensive effects of far-infrared ray irradiated from wooden board in spontaneously hypertensive rats.BMC complementary and alternative medicine · 2016Article
- Sterol Regulatory Element-Binding Protein-1c Regulates Inflammasome Activation in Gingival Fibroblasts Infected with High-Glucose-TreatedFrontiers in cellular and infection microbiology · 2016Article
- Fulvic acid attenuates homocysteine-induced cyclooxygenase-2 expression in human monocytes.BMC complementary and alternative medicine · 2015Article
- Differential regulation of human aortic smooth muscle cell proliferation by monocyte-derived macrophages from diabetic patients.PloS one · 2014Article
- Shear stress modulates macrophage-induced urokinase plasminogen activator expression in human chondrocytes.Arthritis research & therapy · 2013Article
- CXC chemokine ligand 12/stromal cell-derived factor-1 regulates cell adhesion in human colon cancer cells by induction of intercellular adhesion molecule-1.Journal of biomedical science · 2012Article
- [Update on diabetic macroangiopathy].Der Pathologe · 2012Review
- Glucose and fatty acid metabolism in a 3 tissue in-vitro model challenged with normo- and hyperglycaemia.PloS one · 2012Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
E-selectin expression by endothelial cells (ECs) is crucial for leukocyte recruitment during the inflammatory response. Macrophage accumulation and serum E-selectin elevation are features of type 2 diabetes mellitus. However, the interactions between macrophages and ECs in regulating vascular endothelial function are not clearly understood. We investigated the mechanisms underlying the modulation of EC E-selectin expression by high glucose (HG)-treated macrophages. Macrophage-conditioned media (MCM) were prepared from HG-treated macrophages. EC stimulation with HG-MCM induced increases the expression and secretion of E-selectin. By using specific inhibitors and small interfering RNAs, we demonstrate that the activation of the JNK and p38 MAPK pathways are critical for HG-MCM-induced E-selectin expression. Transcription factor ELISA and chromatin immunoprecipitation assays further showed that HG-MCM increases the NF-κB- and AP-1 DNA-binding activities in ECs. The inhibition of NF-κB and AP-1 activation by specific siRNAs blocks the HG-MCM-induced E-selectin promoter activity and expression. Protein arrays and blocking assays using neutralizing antibodies demonstrated that macrophage inflammatory protein 1α and 1β in HG-MCM are major mediators for the induction of EC E-selectin expression. These data support the hypothesis that E-selectin up-regulation stimulated by macrophages may play an active role in atherogenesis in the HG condition and suggest a new mechanism by which arterial disease is accelerated in diabetes.
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