ArticleDiabetes2011
Storage of circulating free fatty acid in adipose tissue of postabsorptive humans: quantitative measures and implications for body fat distribution.
Article in Diabetes, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
64 citing papers in PubMed, 87 citations in OpenAlex.
- Adipocyte Proteins and Storage of Endogenous Fatty Acids in Visceral and Subcutaneous Adipose Tissue in Severe Obesity.Obesity (Silver Spring, Md.) · 2021Trial
- Regulation of direct adipose tissue free fatty acid storage during mixed meal ingestion and high free fatty acid concentration conditions.American journal of physiology. Endocrinology and metabolism · 2021Trial
- Subcutaneous adipose tissue free fatty acid uptake measured using positron emission tomography and adipose biopsies in humans.American journal of physiology. Endocrinology and metabolism · 2019Trial
- Acute Testosterone Deficiency Alters Adipose Tissue Fatty Acid Storage.The Journal of clinical endocrinology and metabolism · 2017Trial
- Effects of acute hypoxia on human adipose tissue lipoprotein lipase activity and lipolysis.Journal of translational medicine · 2016Trial
- Adipose Tissue Free Fatty Acid Storage In Vivo: Effects of Insulin Versus Niacin as a Control for Suppression of Lipolysis.Diabetes · 2015Trial
- Measuring plasma fatty acid oxidation with intravenous bolus injection of 3H- and 14C-fatty acid.Journal of lipid research · 2013Trial
- Effects of male hypogonadism on regional adipose tissue fatty acid storage and lipogenic proteins.PloS one · 2012Trial
- Circulating Liver-Derived and CD36Journal of extracellular vesicles · 2026Article
- Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans.Physiological reviews · 2025Review
- The Role of TLRs in Obesity and Its Related Metabolic Disorders.International journal of molecular sciences · 2025Review
- Relatively lower BMI-adjusted calf circumference is associated with metabolically unhealthy phenotype in non-obese adults: a cross-sectional study.BMC public health · 2024Article
- FGF21 mediating the Sex-dependent Response to Dietary Macronutrients.The Journal of clinical endocrinology and metabolism · 2024Review
- The pathophysiology of visceral adipose tissues in cardiometabolic diseases.Biochemical pharmacology · 2024Review
- Visceral Adipose Tissue: The Hidden Culprit for Type 2 Diabetes.Nutrients · 2024Review
- Article
- Macrophages Upregulate Estrogen Receptor Expression in the Model of Obesity-Associated Breast Carcinoma.Cells · 2022Article
- Effects of SGLT2 inhibition on lipid transport in adipose tissue in type 2 diabetes.Endocrine connections · 2022Article
- Non-alcoholic Fatty Liver Disease and Steatohepatitis: Risk Factors and Pathophysiology.Middle East journal of digestive diseases · 2022Review
- Comparative Transcriptome Analysis Provides Insight into Spatio-Temporal Expression Characteristics and Genetic Regulatory Network in Postnatal Developing Subcutaneous and Visceral Fat of Bama Pig.Frontiers in genetics · 2022Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivePreferential upper-body fat gain, a typical male pattern, is associated with a greater cardiometabolic risk. Regional differences in lipolysis and meal fat storage cannot explain sex differences in body fat distribution. We examined the potential role of the novel free fatty acid (FFA) storage pathway in determining body fat distribution in postabsorptive humans and whether adipocyte lipogenic proteins (CD36, acyl-CoA synthetases, and diacylglycerol acyltransferase) predict differences in FFA storage. RESEARCH DESIGN AND
methodsRates of postabsorptive FFA (palmitate) storage into upper-body subcutaneous (UBSQ) and lower-body subcutaneous (LBSQ) fat were measured in 28 men and 53 premenopausal women. Stable and radiolabeled palmitate tracers were intravenously infused followed by subcutaneous fat biopsies. Body composition was assessed with a combination of dual-energy X-ray absorptiometry and computed tomography.
resultsWomen had greater FFA (palmitate) storage than men in both UBSQ (0.37 ± 0.15 vs. 0.27 ± 0.18 μmol · kg(-1) · min(-1), P = 0.0001) and LBSQ (0.42 ± 0.19 vs. 0.22 ± 0.11 μmol · kg(-1) · min(-1), P < 0.0001) fat. Palmitate storage rates were significantly greater in LBSQ than UBSQ fat in women, whereas the opposite was true in men. Plasma palmitate concentration positively predicted palmitate storage in both depots and sexes. Adipocyte CD36 content predicted UBSQ palmitate storage and sex-predicted storage in LBSQ fat. Palmitate storage rates per kilogram fat did not decrease as a function of fat mass, whereas lipolysis did.
conclusionsThe FFA storage pathway, which had remained undetected in postabsorptive humans until recently, can have considerable, long-term, and sex-specific effects on body fat distribution. It can also offer a way of protecting the body from excessive circulating FFA in obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.